56 results found
    1. Medicine

    Loss of the melanocortin-4 receptor in mice causes dilated cardiomyopathy

    Michael J Litt et al.
    The melanocortin-4 receptor knockout mouse exhibits a cardiomyopathy syndrome, which raises concerns about cardiovascular function in patients with the similar loss of function mutations, and perhaps even in the 1 in 1500 patients with heterozygous loss of the gene.
    1. Microbiology and Infectious Disease

    Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic Archaea

    Dipti D Nayak et al.
    Post-translational installation of thioglycine in methyl-coenzyme M reductase in the methanogenic archaeon Methanosarcina acetivorans is mediated by the tfuA-ycaO locus and stabilizes the protein secondary structure near the active site.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genetic mapping of etiologic brain cell types for obesity

    Pascal N Timshel et al.
    Unbiased computational integration of single-cell- and human genetics data shows that susceptibility to obesity is driven by a broad set of neuronal populations across the brain.
    1. Genetics and Genomics

    Ancient mechanisms for the evolution of the bicoid homeodomain's function in fly development

    Qinwen Liu et al.
    Transgenic animals carrying reconstructed ancestral alleles reveal how two ancient mutations allowed a regulatory protein to evolve a controlling role in embryonic development in flies.
    1. Neuroscience

    Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit

    Giuseppe D'Agostino et al.
    A novel and distinct cholecystokinin brain circuit critically modulates food intake and body weight.
    1. Cell Biology
    2. Neuroscience

    The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1

    Anna L Chaly et al.
    A non-melanocortin G-protein coupled receptor is inhibited by the Melanocortin Receptor Accessory Protein 2 (MRAP2) to control food intake in mammals.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A Fyn biosensor reveals pulsatile, spatially localized kinase activity and signaling crosstalk in live mammalian cells

    Ananya Mukherjee et al.
    Unique biosensor design and protein-engineering enables direct visualization of the active form of Fyn kinase with high specificity, minimal perturbation and shows cellular signaling to be compartmentalized and pulsatile.
    1. Cell Biology
    2. Neuroscience

    Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice

    Damien Lanfray et al.
    The Acyl-CoA binding domain-containing 7 (Acbd7) gene is expressed in the hypothalamus, encodes a peptide that suppresses appetite, increases metabolic rate and interacts with the leptin-melanocortin system.
    1. Cancer Biology
    2. Developmental Biology

    A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC)

    Imelda T Sandoval et al.
    The tumor suppressor APC regulates a metabolic program that drives normal intestinal differentiation in zebrafish.
    1. Biochemistry and Chemical Biology

    Structural and functional characterization of G protein–coupled receptors with deep mutational scanning

    Eric M Jones et al.
    Linking deep mutational scanning with engineered transcriptional reporters in human cell lines establishes a generalizable method for exploring pharmacogenomics, structure, and function across broad classes of drug receptors.

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