1,651 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Analysis of the crystal structure of an active MCM hexamer

    Justin M Miller et al.
    Building on previous work (Froelich et al., 2014), we present the X-ray crystal structure of an active MCM hexamer, which suggests a mechanism for MCM regulation and demonstrates a key interaction between the major domains.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A conserved MCM single-stranded DNA binding element is essential for replication initiation

    Clifford A Froelich et al.
    The crystal structure of the MCM helicase bound to single-stranded DNA reveals a binding motif that is critical for cell viability, helicase activation and DNA replication.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome

    Alessandro Costa et al.
    The Mcm2-7 motor unwinds DNA using an approach distinct from that of superfamily III helicases, and accesses multiple ring configurations and assembly states during the initiation of DNA replication.
    1. Chromosomes and Gene Expression

    MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion

    Ge Zheng et al.
    Systematic analyses of DNA replication machinery components in human cells reveal a requirement of MCM-dependent de novo loading or mobilization of cohesin at replication forks in establishing sister-chromatid cohesion.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    A conserved Mcm4 motif is required for Mcm2-7 double-hexamer formation and origin DNA unwinding

    Kanokwan Champasa et al.
    Analysis of an essential motif in Mcm4 provides insights into replicative helicase double-hexamer formation and the first step requiring this intermediate during replication initiation.
    1. Developmental Biology

    The Glide/Gcm fate determinant controls initiation of collective cell migration by regulating Frazzled

    Tripti Gupta et al.
    The role of the Frazzled chemoattractant receptor is to triggers migration initiation as part of the glial developmental program induced by the Glide/Gcm transcription factor.
    1. Biochemistry and Chemical Biology

    Amidst multiple binding orientations on fork DNA, Saccharolobus MCM helicase proceeds N-first for unwinding

    Himasha M Perera, Michael A Trakselis
    The archaeal MCM helicase can load in multiple orientations on DNA but translocation proceeds with a leading N-terminal domain, which affects double hexamer activation at origins of replication.
    1. Neuroscience

    Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy

    Chi Jung Hung et al.
    New transgenic mice, which can be ablated both orexin neurons and MCH neurons, showed new brain state and revealed functional interaction that MCH neurons have protective role in narcolepsy symptoms.
    1. Cell Biology
    2. Developmental Biology

    A feedback mechanism converts individual cell features into a supracellular ECM structure in Drosophila trachea

    Arzu Öztürk-Çolak et al.
    Cell-cell junctions and the actin cytoskeleton are key players in the organisation and patterning of the extracellular matrix (ECM) on the apical side of tracheal cells.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex

    Charles B Phillips et al.
    Biochemical analysis reveals molecular mechanisms underlying the activation of the mitochondrial Ca2+ uniporter by intracellular Ca2+ signals.

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