2,430 results found
  1. Blue and black pixels

    Episode 66: May 2020

    In this episode we hear about sparrows, cave-dwelling fish, COVID-19 in hospital staff, anti-fungal drugs and lack of insect diversity in soil.
    1. Chromosomes and Gene Expression
    2. Cell Biology

    Aging, Geroscience and Longevity: A Special Issue

    Edited by Matt Kaeberlein et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of aging and interventions that extend longevity.
    1. Computational and Systems Biology

    Cell-cycle-gated feedback control mediates desensitization to interferon stimulation

    Anusorn Mudla et al.
    Cell cycle gating enables a temporal compartmentalization of negative vs positive feedback control processes, leading to differential responses to repetitive interferon stimulations.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    A virus-encoded protein suppresses methylation of the viral genome through its interaction with AGO4 in the Cajal body

    Liping Wang et al.
    The Cajal body is essential for plants to deploy antiviral DNA methylation.
    1. Cell Biology

    Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness

    Arpit Sharma et al.
    Skeletal muscle mitochondrial pyruvate carrier disruption increases muscle fatty acid oxidation and systemic glucose turnover that drive whole-body leanness.
    1. Developmental Biology
    2. Plant Biology

    Coordination of tissue cell polarity by auxin transport and signaling

    Carla Verna et al.
    GNOM controls both auxin transport and auxin signaling to coordinate tissue cell polarity during vein patterning in plants.
    1. Immunology and Inflammation

    Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

    Ankit Jambusaria et al.
    Vascular endothelial cells in the brain, heart and lung exhibit tissue-specific heterogeneity and plasticity, expressing genes that were traditionally thought to be only expressed by the surrounding parenchymal tissue cells.
    1. Cell Biology

    Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases

    King Faisal Yambire et al.
    Transcription factors KLF2 and ETV1 repress the transcriptional program of mitochondrial biogenesis, resulting in impaired mitochondrial function in lysosomal storage diseases.
    1. Cell Biology

    Cyclin-dependent kinase control of motile ciliogenesis

    Eszter K Vladar et al.
    Cyclin-dependentkinase 2 (Cdk2), the master regulator of S phase events during the cell cycle, controls the earliest step in the motile ciliogenesis pathway in quiescent multiciliatedairway epithelial cells.
    1. Developmental Biology

    Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain

    Sylvie Remaud et al.
    Production of remyelinating subventricular zone oligodendrocyte progenitors is stimulated by transient abrogation of thyroid hormone signalling in the adult neural stem cell niche.

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