95 results found
    1. Evolutionary Biology

    Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia

    Matthias Merker et al.
    The genetic make-up of dominating MDR-TB clades in Central Asia is shaped by programmatic and socio-economic changes that led to fixation of resistance and bacterial fitness related mutations in the Soviet era.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Point of View: Tuberculosis innovations mean little if they cannot save lives

    Madhukar Pai, Jennifer Furin
    Ending the TB epidemic requires scaling up access to new TB tools so that they can benefit the patients in low- and middle-income countries that need them the most.
    1. Biochemistry and Chemical Biology

    Antibiotics: A new spanner in the works of bacterial transcription

    Kristine B Arnvig, Finn Werner
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    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment

    James E Gomez et al.
    Mutations in several components of a bacterial ribosome are shown to broadly decrease antibiotic and stress sensitivity, and readily accessible reversion mutations allow these ribosomal mutations to serve as stepping stones to high level antibiotic resistance.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Extensive cargo identification reveals distinct biological roles of the 12 importin pathways

    Makoto Kimura et al.
    Transport-based high-throughput identification of cargo proteins specific to all 12 human importin-β family nuclear import receptors revealed biological processes that the cargo cohorts of each receptor are involved in.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans

    Murilo Delgobo et al.
    Mycobacterium tuberculosis exploits an IFN/IL6/CEBP axis linked to monocyte expansion in humans.
    1. Cell Biology

    The transcription factor Hey and nuclear lamins specify and maintain cell identity

    Naama Flint Brodsly et al.
    Hey together with LaminC continuously supervise nuclear organisation and differentiated enterocyte identity, a regulation that is lost upon ageing, resulting in loss of gut homeostasis.
    1. Immunology and Inflammation
    2. Physics of Living Systems

    Light-based tuning of ligand half-life supports kinetic proofreading model of T cell signaling

    Doug K Tischer, Orion David Weiner
    Direct control of ligand binding half-life with light shows that lifetime strongly affects T cell signaling.
    1. Microbiology and Infectious Disease

    High-resolution mapping of fluoroquinolones in TB rabbit lesions reveals specific distribution in immune cell types

    Landry Blanc et al.
    Penetration of the fluoroquinolones in tuberculosis lesions is heterogeneous even in fully cellular areas, is driven by macrophage content and decreases as the distance from lesion outer rim increases.
    1. Cancer Biology
    2. Cell Biology

    Aurora kinase A localises to mitochondria to control organelle dynamics and energy production

    Giulia Bertolin et al.
    AurkA is imported into mitochondria at interphase, and it induces organelle elongation and enhances ATP production when over-expressed.

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