6,005 results found
    1. Developmental Biology
    2. Evolutionary Biology

    Characterization of the finch embryo supports evolutionary conservation of the naive stage of development in amniotes

    Siu-Shan Mak, Cantas Alev ... Raj K Ladher
    Finch embryos are laid at an earlier stage than other avian embryos and contain cells with similar properties to pluripotent embryonic stem cells from mice.
    1. Epidemiology and Global Health

    The impact of COVID-19 on cancer screening and treatment in older adults: The Multiethnic Cohort Study

    Victoria P Mak, Kami White ... Loic Le Marchand
    During the COVID-19 pandemic, cancer-related screening and healthcare practices varied (by age, race/ethnicity, education, and comorbidities), and considering these differences in high-risk individuals' monitoring is important as undiagnosed cases or poor prognosis may increase due to delayed screening/treatment.
    1. Cell Biology
    2. Developmental Biology

    Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3

    Jarrett Smith, Deepika Calidas ... Geraldine Seydoux
    A competition for RNA drives the localized assembly of RNA granules in the C. elegans embryo.
    1. Developmental Biology

    Osteocalcin expressing cells from tendon sheaths in mice contribute to tendon repair by activating Hedgehog signaling

    Yi Wang, Xu Zhang ... Kingston King-Lun Mak
    Cells in tendon sheaths, considered to be extrinsic tissues of tendon, possess stem or progenitor cell properties that are involved in tendon repair by activating the Hh-TGFb/Smad3 axis.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Molecular mechanism for direct actin force-sensing by α-catenin

    Lin Mei, Santiago Espinosa de los Reyes ... Gregory M Alushin
    Biophysical and structural studies reveal how low piconewton forces across actin enhance binding by the critical cell-cell adhesion protein α-catenin versus its force insensitive homolog vinculin.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance

    Rebecca EK Mandt, Madeline R Luth ... Amanda K Lukens
    The mutational flexibility of the antimalarial target dihydroorotate dehydrogenase thwarts the use of collateral sensitivity as a strategy to suppress the evolution of resistance.
    1. Neuroscience

    A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome

    Guanglin Xing, Hongyang Jing ... Lin Mei
    Asparagine 88 to lysine (N88K), a prevalent congenital myasthenic syndrome mutation of Rapsyn, impairs the neuromuscular junction by disrupting agrin signaling.
    1. Structural Biology and Molecular Biophysics

    ER-luminal [Ca2+] regulation of InsP3 receptor gating mediated by an ER-luminal peripheral Ca2+-binding protein

    Horia Vais, Min Wang ... Don-On Daniel Mak
    Calcium release from the endoplasmic reticulum through the IP3 receptor ion channel is strongly regulated by a calcium-binding protein in the lumen of the endoplasmic reticulum.
    1. Medicine

    Senescent preosteoclast secretome promotes metabolic syndrome associated osteoarthritis through cyclooxygenase 2

    Weiping Su, Guanqiao Liu ... Mei Wan
    Under metabolic syndrome, joint subchondral preosteoclasts acquire a senescence-associated secretome, which causes a rapid structural alteration of subchondral bone and contributes to the development of osteoarthritis.
    1. Physics of Living Systems

    Optical mapping of ground reaction force dynamics in freely behaving Drosophila melanogaster larvae

    Jonathan H Booth, Andrew T Meek ... Malte C Gather
    A new optical approach reveals dynamics of ground reaction forces in Drosophila larvae and opens new avenues for studying the biomechanics of movement in small animals.

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