1,093 results found
    1. Cell Biology

    The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis

    Philipp Kimmig et al.
    A unique form of regulation has been observed in the unfolded protein response of S. pombe, along with a novel mechanism of post-transcriptional mRNA processing.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A novel role for lipid droplets in the organismal antibacterial response

    Preetha Anand et al.
    Histones bound to lipid droplets inside cells offer protection against bacteria in flies, and possibly mice, thus suggesting a possible new innate immunity pathway.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

    Brian J Ferguson et al.
    Experiments in mice have shown than an enzyme that repairs broken DNA inside the nucleus also has a central role in the innate immune system because it is able to detect foreign DNA outside the nucleus.
    1. Cell Biology
    2. Developmental Biology

    Dual functions of TAF7L in adipocyte differentiation

    Haiying Zhou et al.
    A combination of cellular, biochemical, genetic and genomic techniques have revealed a new molecular player in the production of fat cells in mice, which could improve our understanding of obesity.
    1. Plant Biology

    A virus responds instantly to the presence of the vector on the host and forms transmission morphs

    Alexandre Martinière et al.
    Cauliflower mosaic virus reacts immediately when aphids feed on the host plant, and this boosts its chances of being taken up and transmitted by the insects to a new plant.
    1. Cell Biology
    2. Immunology and Inflammation

    UNC93B1 mediates differential trafficking of endosomal TLRs

    Bettina L Lee et al.
    A transmembrane protein uses distinct mechanisms to regulate the movement of specific toll-like receptors-key immune system components involved in detecting pathogens-to their final locations inside cells.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Mechanism for priming DNA synthesis by yeast DNA Polymerase α

    Rajika L Perera et al.
    The details of how the enzyme DNA polymerase α initiates the polymerization of nucleotides in DNA replication, a critical step in the synthesis of new chromosomal DNA, have been revealed in atomic detail.
    1. Neuroscience

    Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2

    Elizabeth D Kirby et al.
    Exposing rats to acute stress increased the generation of new neurons in a subregion of the hippocampus, and improved the animals' performance in a memory task two weeks later.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

    Jiajie Diao et al.
    Experiments on synthetic models of synaptic vesicles have shed new light on the role of the protein α-synuclein in the central nervous system.
    1. Cell Biology

    Stapled Golgi cisternae remain in place as cargo passes through the stack

    Gregory Lavieu et al.
    The cisternae of the Golgi contain two functionally distinct domains: the central areas, which remain stationary, and the edges or rims, which are mobile.

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