1,135 results found
    1. Microbiology and Infectious Disease

    Coordination of humoral immune factors dictates compatibility between Schistosoma mansoni and Biomphalaria glabrata

    Hongyu Li et al.
    A coordinated humoral immune response that includes recognition, effector and cytotoxic factors engages the cell-mediated immune response to defend a snail against infection by schistosome parasites.
    1. Cell Biology
    2. Developmental Biology

    Hair follicle stem cells regulate retinoid metabolism to maintain the self-renewal niche for melanocyte stem cells

    Zhiwei Lu et al.
    Metabolite mediates communication between stem cells and influences stem cell maintenance.
    1. Cancer Biology
    2. Developmental Biology

    Regulation of zebrafish melanocyte development by ligand-dependent BMP signaling

    Alec K Gramann et al.
    The oncogenic role ligand-dependent BMP signaling plays in suppressing differentiation in melanoma is a reiteration of its physiological roles during melanocyte development.
    1. Neuroscience

    Homeostatic regulation of perisynaptic matrix metalloproteinase 9 (MMP9) activity in the amblyopic visual cortex

    Sachiko Murase et al.
    Dark exposure lowers the MMP9 activation threshold, and subsequent light stimulation to an amblyopic eye is sufficient to induce proteolysis at thalamo-cortical synapses in deprived mouse visual cortex.
    1. Neuroscience

    mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking

    Nadege Morisot et al.
    In the orbitofrontal cortex, mTORC1, a multiprotein complex centered around the kinase mTOR, contributes to the development and/or maintenance of habitual alcohol seeking.
    1. Cell Biology

    Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model

    Magdalena Kasendra et al.
    Combining Organs-on-Chips technology with adult intestinal organoids provides an improved model of human duodenum and a new platform for preclinical drug assessment.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

    Ricardo Guerrero-Ferreira et al.
    Two new polymorphic structures of recombinant human alpha-synuclein fibrils show striking differences to previous structures, while familial PD mutation sites remain crucial for protofilament interaction and fibril stability.
    1. Cell Biology
    2. Immunology and Inflammation

    A role for phagocytosis in inducing cell death during thymocyte negative selection

    Nadia S Kurd et al.
    Self-reactive thymocyte death is most efficient when peptide-presenting cells are phagocytic, and blocking phagocytosis inhibits self-reactive thymocyte death, suggesting that phagocytes play central roles during thymocyte negative selection.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion

    Ivana Strazic Geljic et al.
    Single mouse cytomegalovirus protein, m154, downmodulates surface expression of numerous targets important for NK and CD8 T cell activation by perturbing adaptor protein-1 sorting and redirecting targets to lysosomal degradation.
    1. Developmental Biology
    2. Genetics and Genomics

    Combinatorial chromatin dynamics foster accurate cardiopharyngeal fate choices

    Claudia Racioppi et al.
    ATAC-seq, CRISPR/Cas9 mutagenesis, reporter and gene expression assays revealed dynamic chromatin accessibility profiles governing differential gene expression during heart vs. pharyngeal muscle fate choices in the powerful chordate model Ciona.

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