1,083 results found
    1. Epidemiology and Global Health
    2. Genomics and Evolutionary Biology

    MERS-CoV spillover at the camel-human interface

    Gytis Dudas et al.
    MERS-CoV infections in the Arabian Peninsula are the result of several hundred spillover events from viruses circulating in camels into the human population.
    1. Developmental Biology and Stem Cells

    Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division

    Jennifer J Banerjee et al.
    Meru is a factor that provides tissue-specific information to the core polarity machinery by linking planar to apical-basal polarity in asymmetrically dividing sensory organ precursors.
    1. Neuroscience

    Testing sensory evidence against mnemonic templates

    Nicholas E Myers et al.
    Visual search templates are reactivated only temporarily to act as input filters for target detection.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology and Stem Cells

    SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells

    Samuel A Myers et al.
    A post-translational modification called O-GlcNAcylation modulates the activity of the SOX2 transcription factor in pluripotent stem cells.
    1. Biochemistry and Chemical Biology
    2. Genes and Chromosomes

    Concerted action of the MutLβ heterodimer and Mer3 helicase regulates the global extent of meiotic gene conversion

    Yann Duroc et al.
    Meiotic cells employ a specific pathway to limit the amount of gene conversion occuring at recombination sites.
    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity

    Michael P Meers et al.
    Post-translational modification of histone H3K36 is not required to suppress cryptic transcription initiation or to include alternative exons in Drosophila; instead it promotes expression of active genes by stimulating polyadenylation.
    1. Biophysics and Structural Biology
    2. Microbiology and Infectious Disease

    Escherichia coli swimming is robust against variations in flagellar number

    Patrick J Mears et al.
    The swimming behavior of E. coli is surprisingly robust against the natural variations in the number of flagella per cell.
    1. Developmental Biology and Stem Cells

    Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons

    Stefanie Seelk et al.
    Increased Notch signaling enhances germ cell reprograming in C. elegans by antagonizing PRC2-mediated repression, which results in the activation of UTX-1 and other reprograming-promoting genes.
    1. Neuroscience

    Cerebral mGluR5 availability contributes to elevated sleep need and behavioral adjustment after sleep deprivation

    Sebastian C Holst et al.
    Multi-modal imaging, genetic and behavioral findings in humans and mice revealed that metabotropic glutamate receptors of subtype 5 contribute to the molecular machinery keeping track of sleep need and coping with physiological and behavioral consequences of sleep loss, pointing to novel targets for improved wakefulness and sleep.
    1. Biophysics and Structural Biology

    Cryo-EM structure of the bifunctional secretin complex of Thermus thermophilus

    Edoardo D'Imprima et al.
    The pilus extrusion/DNA uptake system of Thermus thermophilus contains a 13-mer of the 757-residue PilQ protein and a tightly bound protein outside the outer membrane with a role in DNA binding.

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