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    1. Microbiology and Infectious Disease

    Acute targeted induction of gut-microbial metabolism affects host clock genes and nocturnal feeding

    Giorgia Greter, Claudia Moresi ... Markus Arnoldini
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing

    Wenbo Liu, Xukun Lu ... Jianqiao Liu
    SRSF10 directly binds genes functioning in spermatogonia and regulates their alternative splicing, the defect of which can lead to progenitor expansion failure.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    SNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants

    Rixing Lin, Aron Kos ... Gustavo Turecki
    A small non-coding RNA, SNORD90, links monoaminergic directed antidepressant treatment with glutamatergic activation.
    1. Developmental Biology
    2. Neuroscience

    A Notch-dependent transcriptional mechanism controls expression of temporal patterning factors in Drosophila medulla

    Alokananda Ray, Xin Li
    Cell-cycle-dependent Notch signaling cooperates with temporal transcription factors to promote the progression of the temporal transcription factor cascade in Drosophila medulla neuroblasts.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A nanobody-based molecular toolkit provides new mechanistic insight into clathrin-coat initiation

    Linton M Traub
    New intracellularly-expressed llama anti-EPS15 nanobodies reveal that pioneer clathrin-coat components function upstream of AP-2 clathrin adaptor deposition at the plasma membrane.
    1. Evolutionary Biology

    Destructive disinfection of infected brood prevents systemic disease spread in ant colonies

    Christopher D Pull, Line V Ugelvig ... Sylvia Cremer
    Upon detecting a fatal infection using chemical cues, ants puncture the cuticle of sick brood and inject antimicrobial poison that disrupts the pathogen's life cycle and prevents it from reproducing, thus protecting the colony from disease.
    1. Structural Biology and Molecular Biophysics

    Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival

    Vladimir Chubanov, Silvia Ferioli ... Thomas Gudermann
    Mice deficient in the TRPM6 channel suffer from impaired prenatal development, shortened lifespan, growth deficit and disturbed energy balance due to a defect in epithelial Mg2+ uptake, thus highlighting a pivotal role of TRPM6 in organismal Mg2+ homeostasis.
    1. Cell Biology

    Pathogenic Huntingtin aggregates alter actin organization and cellular stiffness resulting in stalled clathrin-mediated endocytosis

    Surya Bansi Singh, Shatruhan Singh Rajput ... Deepa Subramanyam
    Neurodegeneration driven by pathogenic aggregating proteins reorganizes the actin cytoskeleton, causing cellular stiffening and abolishing force generation required for endocytic events.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    eIF3 engages with 3’-UTR termini of highly translated mRNAs

    Santi Mestre-Fos, Lucas Ferguson ... Jamie HD Cate
    The extent of human eukaryotic translation initiation factor eIF3 interaction with the 3' ends of mRNA 3' untranslated regions (3'-UTRs) correlates with the level of translation.