4,189 results found
    1. Cell Biology
    2. Immunology and Inflammation

    Regulation of B cell fate by chronic activity of the IgE B cell receptor

    Zhiyong Yang et al.
    The immunoglobulin E (IgE) B cell receptor promotes plasma cell differentiation in the absence of cognate antigen and limits the competitive fitness of IgE+ B cells in germinal centers.
    1. Epidemiology and Global Health

    External validation of postnatal gestational age estimation using newborn metabolic profiles in Matlab, Bangladesh

    Malia SQ Murphy et al.
    Gestational age estimation models derived from newborn screening bloodspot samples are effective on data obtained from both heel prick and cord blood samples in low-resource settings.
    1. Cancer Biology

    Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness

    Haritha Mathsyaraja et al.
    The MYC transcription factor network member MGA is a subunit of a non-canonical Polycomb complex, which, when inactivated, accelerates tumorigenesis in mouse models of cancer and proliferation in colon organoids.
    1. Cancer Biology
    2. Immunology and Inflammation

    Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth

    Mark David Hayes et al.
    Natural IgE supports epithelial cell growth and differentiation in healthy skin, but during chronic tissue inflammation, IgE drives tumour outgrowth of epithelial cells harbouring oncogenic mutations.
    1. Structural Biology and Molecular Biophysics

    Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR

    Tatsuro Maruyama et al.
    Nuclear magnetic resonance analysis revealed the structural and dynamical changes in MgtE during the channel closure caused by the cooperative Mg2+-binding, which had remained undescribed only by a static crystal structure.
    1. Developmental Biology
    2. Neuroscience

    Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts

    Christine J Huh et al.
    MicroRNA-based direct conversion of human fibroblasts to neurons is applicable to fibroblasts from donors ranging in age from neonatal to centenarian, allowing the generation of neurons that maintain the age-associated signatures of the starting fibroblasts.
    1. Neuroscience

    Monkey EEG links neuronal color and motion information across species and scales

    Florian Sandhaeger et al.
    Using Monkey EEG as a bridge technology, color and motion representations in human MEG are linked to microcircuit activity in ventral stream areas.
    1. Neuroscience

    Human Neocortical Neurosolver (HNN), a new software tool for interpreting the cellular and network origin of human MEG/EEG data

    Samuel A Neymotin et al.
    Human Neocortical Neurosolver is a new user-friendly software tool for researchers to develop and test hypotheses on cellular/circuit origins of human MEG/EEG signals using a biophysical model.
    1. Immunology and Inflammation

    Latent gammaherpesvirus exacerbates arthritis through modification of age-associated B cells

    Isobel C Mouat et al.
    Latent gammaherpesvirus infection predisposes mice to develop more severe disease following induction of arthritis by elevating pathogenic interferon-gamma-expressing age-associated B cells.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Sister kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effect

    Agata P Zielinska et al.
    Multiple age-related changes in chromosome architecture could explain why human oocyte aneuploidy increases with advanced maternal age.

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