2,097 results found
    1. Cell Biology
    2. Immunology and Inflammation

    TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway

    Andreas Neerincx et al.
    The recently discovered peptide editor TAPBPR binds to UDP-glucose:glycoprotein glucosyltransferase 1 to provide quality control in the antigen presentation pathway by facilitating the reglucosylation of the glycan on MHC class I molecules.
    1. Cancer Biology
    2. Immunology and Inflammation

    Contagious Cancers: A ‘devil’ of a problem

    Victoria L Hansen, Robert D Miller
    The discovery of a second facial tumor disease in the Tasmanian devil has provided insights into the emergence of contagious cancers.
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    1. Cancer Biology

    Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13

    Mei Zeng et al.
    A multi-transcriptional CDKs inhibitor suppresses MYC and induces regression of ovarian tumors, indicating that targeting CDK7, 12, 13 with THZ1 may be an effective approach for treating MYC-dependent malignancies.
    1. Immunology and Inflammation

    Functionally diverse human T cells recognize non-microbial antigens presented by MR1

    Marco Lepore et al.
    MR1T cells are human polyclonal T cells endowed with diverse effector functions in response to endogenous antigens presented by MHC-class 1-related molecule, MR1.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Cytoskeleton: The mother of all actins?

    Felipe Merino, Stefan Raunser
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    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Viruses: The secrets of the stability of the HIV-1 capsid

    Martin Obr, Hans-Georg Kräusslich
    Structural and biophysical studies help to follow the disassembly of the HIV-1 capsid in vitro, and reveal the role of a small molecule called IP6 in regulating capsid stability.
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    1. Neuroscience

    Obesity: The emerging neurobiology of calorie addiction

    Cristina García-Cáceres, Matthias H Tschöp
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    1. Neuroscience

    Point of View: Predictive regulation and human design

    Peter Sterling
    Why does the human regulatory system, which evolution tuned for small satisfactions, now constantly demand 'more'?

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