133 results found
    1. Cell Biology
    2. Developmental Biology

    Mitochondrial fusion is required for spermatogonial differentiation and meiosis

    Grigor Varuzhanyan et al.
    Mitochondrial fusion enables a metabolic transition during spermatogenesis.
    1. Developmental Biology
    2. Neuroscience

    Extracellular matrix-inducing Sox9 promotes both basal progenitor proliferation and gliogenesis in developing neocortex

    Ayse Güven et al.
    Transcription factor Sox9 has an important role in neocortex expansion, where its expression in basal progenitors increases proliferation, induces premature gliogenesis and promotes the expression of extracellular matrix components.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of a bacterial ATP synthase

    Hui Guo et al.
    Construction of a first atomic model for an intact bacterial ATP synthase allows for a structural understanding of the roles of individual amino acids in the mechanism of ATP synthesis.
    1. Microbiology and Infectious Disease

    High-resolution mapping of fluoroquinolones in TB rabbit lesions reveals specific distribution in immune cell types

    Landry Blanc et al.
    Penetration of the fluoroquinolones in tuberculosis lesions is heterogeneous even in fully cellular areas, is driven by macrophage content and decreases as the distance from lesion outer rim increases.
    1. Developmental Biology

    Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment

    Lori L O'Brien et al.
    Wnt11 maintains nephron progenitor niche integrity during kidney development through its modulation of cellular dynamics.
    1. Neuroscience

    Tracking individual action potentials throughout mammalian axonal arbors

    Milos Radivojevic et al.
    A method was developed to non-invasively and simultaneously track individual action-potentials propagating across multiple branches of identified neurons in neocortical cultures.
    1. Cell Biology
    2. Developmental Biology

    Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing

    Sabine Schürmann et al.
    Proteolysis of lipidated N-terminal peptides that tether Hedgehog morphogens to the surface of source cells is absolutely required for their coupled release and bioactivation in vivo in Drosophila melanogaster.
    1. Computational and Systems Biology
    2. Ecology

    Place recognition using batlike sonar

    Dieter Vanderelst et al.
    Echolocating bats may recognize locations in the environment (and navigate to them) by remembering the specific echo signature of those locations.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates

    Tijana Ivanovic et al.
    Long-lived intermediate states formed by glycoprotein catalysts are an essential part of the process used by influenza virus particles to infect cells.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering

    Friso S Aalbers et al.
    By combining structure-based computational predictions and a thorough structural analysis, a highly thermostable enzyme, alcohol dehydrogenase, has been engineered.

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