The absolute affinities of thousands of variant antibodies are measured in parallel using a combination of cell sorting and high-throughput DNA sequencing.

Progesterone mediates nongenomic signaling in Xenopus oocyte meiosis by activating a PLA2 activity that requires two membrane receptors ABDH2 and mPRß.

Plasmodium parasite transcription shifts dramatically along asexual development, and transmission stages variably express important immune evasion genes, suggesting much interesting biology has until now been hidden by bulk analyses.

Two competing descriptions of membrane-less sub-compartments, liquid droplets and polymer binding aggregates, can be cast into a common theoretical framework and tested through single-particle tracking experiments.

Mammalian neural stem cells specifically regulate a subset of astral microtubules to govern the subtle changes in spindle orientation that underlie symmetric vs asymmetric cell division during embryonic cortical neurogenesis.

Phosphorylation of the phosphatase SHP-1 by PKC-θ in natural killer (NK) cells induces SHP-1 inhibition, revealing a novel molecular pathway that sustains NK cell activation threshold.

Neural progenitors in humans and chimpanzee organoids show remarkably similar cellular and molecular parameters, but metaphase is longer during human mitosis.

Blocking the bacterial lipid flippase MprF by monoclonal antibodies enhance staphylococcal clearance by host defense and antibiotics providing a novel proof of concept for antivirulence approaches targeting bacterial resistance mechanisms.

Functional characterization of a pair of cis-encoded antisense RNAs reveals a role for RNase III and antisense regulation in the biogenesis and regulatory activity of a bacterial virulence factor-regulating small RNA.

Key functional variants, discovered using Massively Parallel Reporter Assay (MPRA) and reporter assays in the context of SARS-CoV-2 infection, support the importance of two critical chemokine receptor genes CCR1 and CCR5 in severe Covid-19 illness.