149 results found
    1. Neuroscience

    Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in C. elegans

    Xi Chen et al.
    Plexin controls the spatial distribution of synapses by locally inhibiting Rap2 small GTPase activity along the axon, and a Rap2 effector, TNIK, which also plays a key role in inhibiting synapse number.
    1. Cell Biology
    2. Neuroscience

    The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1

    Anna L Chaly et al.
    A non-melanocortin G-protein coupled receptor is inhibited by the Melanocortin Receptor Accessory Protein 2 (MRAP2) to control food intake in mammals.
    1. Cell Biology
    2. Neuroscience

    Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain

    Ronit Ilouz et al.
    High-resolution, large-scale immunohistochemical mouse brain images showing global views of different brain regions, as well as cellular and subcellular details, identified distinct localization of PKA RIβ and RIIβ regulatory subunits that reveal functional differences.
    1. Cell Biology
    2. Developmental Biology

    circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation

    Anne Kruse Hollensen et al.
    A neuron-specific circular RNA keeps neuronal differentiation in check by lowering transcription rates from key neuronal marker genes.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy

    Dina Simkin et al.
    An inducedpluripotent stem cell (iPSC)-based model of KCNQ2-associated developmental epileptic encephalopathy suggests that disease is driven by dyshomeostaic neuronal mechanisms that are downstream of loss of M-current.
    1. Cell Biology
    2. Neuroscience

    Latrophilin GPCR signaling mediates synapse formation

    Richard Sando, Thomas C Südhof
    Spatial restriction of GPCR signaling at nascent synapses by adhesion complexes drives excitatory synapse formation and specificity in the hippocampus.
    1. Developmental Biology
    2. Neuroscience

    Extracellular Pgk1 enhances neurite outgrowth of motoneurons through Nogo66/NgR-independent targeting of NogoA

    Cheng Yung Lin et al.
    The amount of secreted Pgk1 is sharply decreased in Rtn4al/NogoA-overexpressed muscle cells, leading to various manifestations of neurodegenerative disease, including denervated neuromuscular junction and failed neurite outgrowth of motoneurons.
    1. Neuroscience

    Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects

    Romana Tomasoni et al.
    Excessive inflammation of the brain in early life predisposes individuals to neurodevelopmental disorders by preventing synapses from developing correctly.
    1. Cancer Biology
    2. Genetics and Genomics

    Antigen presentation and tumor immunogenicity in cancer immunotherapy response prediction

    Shixiang Wang et al.
    Tumor immunogenicity is quantified with a novel method, and the resulting tumor immunogenicity score is an effective tumor-inherent biomarker for prediction of response to immune checkpoint inhibitors.
    1. Neuroscience

    Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination

    Brian W Jones et al.
    The PKA anchoring protein, AKAP7, localizes PKA in dentate granule mossy fibers and this localization plays an important role in contextual discrimination and cAMP-induced synaptic plasticity.

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