45 results found
    1. Genetics and Genomics

    Dynamics and regulatory roles of RNA m6A methylation in unbalanced genomes

    Shuai Zhang, Ruixue Wang ... Lin Sun
    Global analyses using aneuploid Drosophila revealed the dynamic roles of RNA m6A modification in regulating gene expression and development under genomic imbalance, highlighting its potential relationships with dosage-related effects.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    N-terminus of Drosophila melanogaster MSL1 is critical for dosage compensation

    Valentin Babosha, Natalia Klimenko ... Oksana Maksimenko
    N‑terminus of MSL1 protein, involved in dosage compensation in Drosophila, is required for the interaction with non-coding roX2 RNA and the assembly of the complex on the male X chromosome.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Drosophila Hamlet mediates epithelial tissue assembly of the reproductive system

    Huazhen Wang, Ludivine Bertonnier-Brouty ... Qi Dai
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Convincing
    1. Genetics and Genomics

    Dysfunction of Calcyphosine-Like gene impairs retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy

    Wenjing Liu, Shujin Li ... Xianjun Zhu
    Genetic analysis and knockout mouse model study identified calcyphosine-like (CAPSL) as a candidate disease gene in familial exudative vitreoretinopathy (FEVR), offering valuable insights into disease mechanisms.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Recent evolutionary origin and localized diversity hotspots of mammalian coronaviruses

    Renan Maestri, Benoît Perez-Lamarque ... Hélène Morlon
    The common ancestor of extant mammalian coronaviruses originated recently in a bat species and their diversification occurred via preferential host switches rather than through codiversification with mammals.
    1. Developmental Biology
    2. Genetics and Genomics

    sisterless A is required for activation of Sex lethal in the Drosophila germline

    Raghav Goyal, Ellen Baxter, Mark Van Doren
    Not revised
    Reviewed Preprint v1
    • Useful
    • Convincing
    • Incomplete
    1. Evolutionary Biology
    2. Genetics and Genomics

    The genomic footprint of social stratification in admixing American populations

    Alex Mas-Sandoval, Sara Mathieson, Matteo Fumagalli
    Social hierarchies resulting from the European colonization of the Americas stratified the population structure, leading to ancestry-related assortative mating and sex bias patterns that can be inferred from the genomes of the populations across the continent.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Efficient estimation for large-scale linkage disequilibrium patterns of the human genome

    Xin Huang, Tian-Neng Zhu ... Guo-Bo Chen
    Leveraging the X-LD method for estimating inter-chromosomal linkage disequilibrium in the human genome uncovers a universal extended LD pattern, consistent with observations in 1KG cohorts.
    1. Plant Biology

    Cell-type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis

    Alicia Kairouani, Dominique Pontier ... Thierry Lagrange
    Musashi-mediated post-transcriptional mechanisms regulate glucuronoxylan modification and secondary cell wall formation in the supportive fibre cells of stem in plants.
    1. Genetics and Genomics

    Sex-specific splicing occurs genome-wide during early Drosophila embryogenesis

    Mukulika Ray, Ashley Mae Conard ... Erica Larschan
    Combining computational and experimental approaches reveals that the loss of a maternal transcription factor influences sex-biased differential splicing in the early zygotic transcriptome at genes that are critical for normal developmental processes.

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