45 results found
    1. Epidemiology and Global Health

    A century of trends in adult human height

    NCD Risk Factor Collaboration (NCD-RisC)
    Height in early adulthood is an indicator that integrates across different dimensions of sustainable human development with links to health and longevity, nutrition, education and economic productivity.
    1. Developmental Biology
    2. Genetics and Genomics

    sisterless A is required for activation of Sex lethal in the Drosophila germline

    Raghav Goyal, Ellen Baxter, Mark Van Doren
    Not revised
    Reviewed Preprint v1
    • Useful
    • Convincing
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Visualizing conformational dynamics of proteins in solution and at the cell membrane

    Sharona E Gordon, Mika Munari, William N Zagotta
    ACCuRET is a flexible new method for measuring the structural dynamics of proteins in solution and membrane proteins in their native environment.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Drosophila Hamlet mediates epithelial tissue assembly of the reproductive system

    Huazhen Wang, Ludivine Bertonnier-Brouty ... Qi Dai
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Convincing
    1. Chromosomes and Gene Expression

    GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo

    Marissa M Gaskill, Tyler J Gibson ... Melissa M Harrison
    Following fertilization, the pioneering transcription factors GAGA factor (GAF) and Zelda are independently required to reprogram the zygotic genome of Drosophila and activate the first wave of gene expression.
    1. Cell Biology
    2. Developmental Biology

    Mitochondrial fusion is required for spermatogonial differentiation and meiosis

    Grigor Varuzhanyan, Rebecca Rojansky ... David C Chan
    Mitochondrial fusion enables a metabolic transition during spermatogenesis.
    1. Cell Biology
    2. Developmental Biology

    Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes

    Danielle Yi, Hai P Nguyen ... Hei Sook Sul
    Dot1l and its H3K79 methyltransferase activity are required for thermogenesis, and Dot1l is recruited by Zc3h10 to its targets genes to alter chromatin accessibility to activate the thermogenic gene program.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Ancient viral genomes reveal introduction of human pathogenic viruses into Mexico during the transatlantic slave trade

    Axel A Guzmán-Solís, Viridiana Villa-Islas ... María C Ávila Arcos
    The characterization of ancient B19V and HBV genotype A4 viruses circulating during Colonial epidemics provides new insights into the pathogens that were introduced to the Americas after the European colonization.
    1. Evolutionary Biology

    Native American genetic ancestry and pigmentation allele contributions to skin color in a Caribbean population

    Khai C Ang, Victor A Canfield ... Keith C Cheng
    Analysis of 458 Kalinago provides new insights into the population's genetic structure, the contribution of Native American ancestry to skin pigmentation, and the identification of a coding variant in OCA2 with an estimated –8 melanin units effect size.
    1. Neuroscience

    Somatostatin-expressing parafacial neurons are CO2/H+ sensitive and regulate baseline breathing

    Colin M Cleary, Brenda M Milla ... Daniel K Mulkey
    Cellular and chemogenetic approaches identify a novel mode of chemotransduction involving regulation of basal breathing by CO2/H+-dependent disinhibition.

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