45 results found
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Mof-associated complexes have overlapping and unique roles in regulating pluripotency in embryonic stem cells and during differentiation

    Sarina Ravens, Marjorie Fournier ... Làszlò Tora
    Two complexes that contain the histone acetyl transferase MOF have distinct regulatory roles in the growth and development of pluripotent embryonic stem cells
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    MOF-associated complexes ensure stem cell identity and Xist repression

    Tomasz Chelmicki, Friederike Dündar ... Asifa Akhtar
    Two complexes that contain the histone acetyl transferase MOF engage in a two-pronged approach to ensure the repression of X inactivation in mouse embryonic stem cells.
    1. Genetics and Genomics

    Dynamics and regulatory roles of RNA m6A methylation in unbalanced genomes

    Shuai Zhang, Ruixue Wang ... Lin Sun
    Global analyses using aneuploid Drosophila revealed the dynamic roles of RNA m6A modification in regulating gene expression and development under genomic imbalance, highlighting its potential relationships with dosage-related effects.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    N-terminus of Drosophila melanogaster MSL1 is critical for dosage compensation

    Valentin Babosha, Natalia Klimenko ... Oksana Maksimenko
    N‑terminus of MSL1 protein, involved in dosage compensation in Drosophila, is required for the interaction with non-coding roX2 RNA and the assembly of the complex on the male X chromosome.
    1. Developmental Biology

    The Drosophila Nab2 RNA binding protein inhibits m6A methylation and male-specific splicing of Sex lethal transcript in female neuronal tissue

    Binta Jalloh, Carly L Lancaster ... Ken Moberg
    The disease-associated RNA binding protein Nab2 is required to inhibit m6A RNA methylation in female Drosophila neuronal tissue and controls key splicing events such as sex-specific splicing of the Sex-lethal RNA.
    1. Genetics and Genomics

    Sex-specific splicing occurs genome-wide during early Drosophila embryogenesis

    Mukulika Ray, Ashley Mae Conard ... Erica Larschan
    Combining computational and experimental approaches reveals that the loss of a maternal transcription factor influences sex-biased differential splicing in the early zygotic transcriptome at genes that are critical for normal developmental processes.
    1. Cell Biology
    2. Plant Biology

    Stretch-activated ion channels identified in the touch-sensitive structures of carnivorous Droseraceae plants

    Carl Procko, Swetha Murthy ... Joanne Chory
    Identification of putative mechanisms for mechanosensation-dependent prey capture in carnivorous plants.
    1. Chromosomes and Gene Expression

    Chromatin-associated RNA sequencing (ChAR-seq) maps genome-wide RNA-to-DNA contacts

    Jason C Bell, David Jukam ... Aaron F Straight
    ChAR-seq is a massively parallelized de novo RNA mapping assay, which is capable of generating hundreds to thousands of RNA-binding maps with no a priori knowledge of target RNAs.
    1. Genetics and Genomics

    Non-allelic gene conversion enables rapid evolutionary change at multiple regulatory sites encoded by transposable elements

    Christopher E Ellison, Doris Bachtrog
    Fully functional regulatory elements can arise rapidly from transposable elements via a novel route where non-allelic gene conversion can act to speed up the evolutionary fine-tuning of regulatory elements.
    1. Chromosomes and Gene Expression

    Cooperation between a hierarchical set of recruitment sites targets the X chromosome for dosage compensation

    Sarah Elizabeth Albritton, Anna-Lena Kranz ... Sevinc Ercan
    Gene regulatory elements can target a chromatin regulatory complex to a single chromosome in the genome through hierarchical specification and long distance cooperation.

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