The therapeutic effects of the sleeping pill zolpidem in patients with disorders of consciousness may be due to recruitment of brain cells idling in abnormally low-frequency brain waves.

Through a combination of modeling and experiments it is shown that humans can near-optimally accumulate decision-related evidence across time and cues even when reaction time is under their control.

Addressing the controversy regarding the interpretation of choice probabilities demonstrates that both readout strategy and noise correlations contribute to the link between neural activity and perceptual decisions.

Studies of Lowe syndrome patient cells, which lack the inositol 5-phosphatase OCRL, suggest that a defect in endocytosis plays a role in the pathological manifestations of the disease.

Endocytosis is triggered by membrane-associated proteins that transform the clathrin adaptor into an active complex.

Interactions in protein complexes can be predicted from evolutionary information from genomic sequences.

A deeply conserved feature of complexin's secondary structure underlies its inhibitory function despite poor primary sequence conservation.

The chaperone protein BiP forms complexes with Ire1 and Perk that dissociate when unfolded proteins bind to BiP to activate the unfolded protein response in the ER.

Nutrient starvation activates autophagy by a novel signaling mechanism that is blocked by one of the major autophagy inhibitors.