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    1. Developmental Biology
    2. Plant Biology

    Organ geometry channels reproductive cell fate in the Arabidopsis ovule primordium

    Elvira Hernandez-Lagana, Gabriella Mosca ... Célia Baroux
    In the Arabidopsis ovule primordium, germinal fate plasticity is coupled to the morphogenetic processes shaping the organ.
    1. Neuroscience

    Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration

    Katerina Rademacher, Zak Doric ... Ken Nakamura
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Computational and Systems Biology
    2. Neuroscience

    A dynamical computational model of theta generation in hippocampal circuits to study theta-gamma oscillations during neurostimulation

    Nikolaos Vardalakis, Amélie Aussel ... Fabien B Wagner
    Combining biophysically realistic hippocampal neurons with coupled phase oscillators that represent theta inputs enables probing the phase-dependent effects of neurostimulation on theta-nested gamma oscillations in normal and pathological states.
    1. Computational and Systems Biology
    2. Neuroscience

    A model for focal seizure onset, propagation, evolution, and progression

    Jyun-you Liou, Elliot H Smith ... LF Abbott
    Usage-dependent inhibition breakdown and neural adaptation underpins the key spatiotemporal dynamics of human focal seizures.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma

    Ariunaa Bayanjargal, Cenny Taslim ... Emily R Theisen
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    The accessory helix of complexin functions by stabilizing central helix secondary structure

    Daniel T Radoff, Yongming Dong ... Jeremy S Dittman
    A deeply conserved feature of complexin's secondary structure underlies its inhibitory function despite poor primary sequence conservation.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Effects of microcompartmentation on flux distribution and metabolic pools in Chlamydomonas reinhardtii chloroplasts

    Anika Küken, Frederik Sommer ... Tabea Mettler-Altmann
    Mathematical models reveal that under the physiologically different conditions ambient and high CO2, two algal microcompartments are metabolically connected by facilitated transport.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Hematopoietic plasticity mapped in Drosophila and other insects

    Dan Hultmark, István Andó
    A critical analysis of recent single-cell transcriptomic studies of Drosophila blood cells confirms the extreme plasticity of the major phagocyte class, identifies a new class of blood cell, and suggests relationships to blood cells in other insects.
    1. Immunology and Inflammation
    2. Neuroscience

    The injured sciatic nerve atlas (iSNAT), insights into the cellular and molecular basis of neural tissue degeneration and regeneration

    Xiao-Feng Zhao, Lucas D Huffman ... Roman J Giger
    Single-cell analysis of injured mouse sciatic nerves reveals rapid reprogramming of macrophages toward a glycolytic, proinflammatory phenotype during the early repair process.
    1. Cell Biology
    2. Developmental Biology

    Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling

    Woong Y Hwang, Valentyna Kostiuk ... Mustafa K Khokha
    β-catenin, a key effector of the Wnt signaling pathway, is transported into the nucleus via a direct interaction between its PY-NLS and TNPO1 offering new potential targets for cancer therapeutics.