1,241 results found
    1. Epidemiology and Global Health

    A century of trends in adult human height

    NCD Risk Factor Collaboration (NCD-RisC)
    Height in early adulthood is an indicator that integrates across different dimensions of sustainable human development with links to health and longevity, nutrition, education and economic productivity.
    1. Medicine
    2. Microbiology and Infectious Disease

    HIV-1 DNA predicts disease progression and post-treatment virological control

    James P Williams, Jacob Hurst ... John Frater
    Measuring HIV-1 DNA levels at the time of stopping antiretroviral therapy (when initiated during primary infection) predicts clinical progression and the time taken for plasma viraemia to become detectable.
    1. Neuroscience

    Circuits that encode and guide alcohol-associated preference

    Kristin M Scaplen, Mustafa Talay ... Karla R Kaun
    Alcohol modifies dopaminergic microcircuits required for acquisition and expression of sensory memories in Drosophila resulting in a shift in behavioral response from malleable to inflexible.
    1. Computational and Systems Biology

    A three filament mechanistic model of musculotendon force and impedance

    Matthew Millard, David W Franklin, Walter Herzog
    Benchmark simulations show that the VEXAT muscle model is more accurate than a Hill-type muscle model at mimicking the response of biological muscle to length changes great and small.
    1. Cancer Biology
    2. Cell Biology

    The out-of-field dose in radiation therapy induces delayed tumorigenesis by senescence evasion

    Erwan Goy, Maxime Tomezak ... Corinne Abbadie
    Irradiation of normal human fibroblasts and mice in conditions mimicking standard external X-ray radiotherapy protocols highlights that noncancerous cells surrounding the planning target volume accumulate DNA single-strand breaks but almost no double-strand breaks, putting them in a pre-cancerous senescent state.
    1. Neuroscience
    2. Physics of Living Systems

    Gigapixel imaging with a novel multi-camera array microscope

    Eric E Thomson, Mark Harfouche ... Eva A Naumann
    A new multi camera imaging platform simultaneously captures large-area, high-resolution video of unconstrained small model organisms and provides behavioral measurements that span multiple spatial scales.
    1. Neuroscience

    Multi-scale mapping along the auditory hierarchy using high-resolution functional UltraSound in the awake ferret

    Célian Bimbard, Charlie Demene ... Yves Boubenec
    Functional UltraSound imaging allows mapping tonotopic organisation in multiple auditory subcortical and cortical brain structures with an unprecedented spatial functional resolution, while giving access to long-distance top-down connectivity pattern from frontal cortex to auditory cortex.
    1. Computational and Systems Biology
    2. Neuroscience

    Towards deep learning with segregated dendrites

    Jordan Guerguiev, Timothy P Lillicrap, Blake A Richards
    A multi-compartment spiking neural network model demonstrates that biologically feasible deep learning can be achieved if sensory inputs and higher-order feedback are received by different dendritic compartments.
    1. Neuroscience

    Transsynaptic mapping of Drosophila mushroom body output neurons

    Kristin M Scaplen, Mustafa Talay ... Karla R Kaun
    Transsynaptic mapping of the postsynaptic connections of mushroom body output neurons reveal both divergent and convergent projections allowing for multimodal integration prior to initiation of an output response.

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