Tatyana Bodrug, Elizabeth M Wilson-Kubalek ... Jawdat Al-Bassam
Biochemical, single molecule, cell and structural biology studies reveal an interaction between the kinesin-5 tail and motor domains regulating high-force production, which is critical for microtubule sliding motility.
MT plus-end-mediated recruitment of a cortical pool of ECT2 trigger RhoA activation upon contact, which results in localized contractility during cytokinesis.
Robyn S Lee, Jean-François Proulx ... William P Hanage
Incorporating within-host diversity in transmission, as identified by deep sequencing, can significantly change previously-held inferences, with major implications for genomic studies of transmission in tuberculosis and other pathogens as well.
Nilkanth Patel, Xi Ping Huang ... Vsevolod Katritch
Large scale virtual screening using recently solved structures of Melatonin receptors yield discovery of 10 new high-affinity selective agonists, also revealing novel functional features, including biased signaling at Melatonin receptors.
A combination of cryo-electron microscopy of TPX2 bound to microtubules and in vitro reconstitution experiments reveals a novel microtubule interaction mode that explains how TPX2 promotes microtubule nucleation and stabilization.
HyungGoo R Kim, Dora E Angelaki, Gregory C DeAngelis
Neural recordings from macaque area MT reveal a novel mechanism for detecting moving objects during self-motion, involving neurons with incongruent tuning for depth from motion parallax and binocular disparity cues.
A detailed description of the structure of procentriole MT triplet by cryoET, along with its associated non-tubulin proteins and its assembly intermediates, reveals possible molecular mechanism for the procentriole assembly.
Purification of two conserved protein complexes, the γ-TuRC and Augmin, using a simple affinity technique, demonstrates that they are necessary and sufficient for the essential phenomenon of branching microtubule nucleation.
