Lack of aryl hydrocarbon receptor ligands in the diet of mice increases the inflammatory state in their epidermis, making cutaneous allergic reactions more severe and airway allergy more pronounced after skin sensitization.
Genetic analysis and biochemical approaches reveal that chemorefractory properties are reversed by inhibiting mucin secretion, thus providing a means to curb the growth and spread of colorectal cancer.
Goblet cells secrete mucins—which are key components of mucus—in a process that is regulated by calcium ions, which enter the goblet cells via a mechanism involving a channel protein called TRPM5.
