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    1. Neuroscience

    A gene-expression-based neural code for food abundance that modulates lifespan

    Eugeni V Entchev, Dhaval S Patel ... QueeLim Ch'ng
    TGFβ and serotonin signaling in a neural circuit encodes food availability; these signals regulate the dynamic range and variability on the circuit to impact coding accuracy and lifespan responses.
    1. Immunology and Inflammation

    A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation

    Huaming Xu, Zhijian Li ... Martin Zenke
    A novel lncRNA marks the Irf8 downstream enhancer that is crucial for differentiation of plasmacytoid dendritic cells (pDC) and classical dendritic cells type 1 (cDC1) and confers feedback inhibition of Irf8 transcription.
    1. Developmental Biology

    A gradient of Wnt activity positions the neurosensory domains of the inner ear

    Magdalena Żak, Nicolas Daudet
    Manipulations of Wnt signalling in the chicken embryo reveal how it controls in a dose-dependent manner the formation of the neurosensory territories of the early developing inner ear.
    1. Ecology
    2. Evolutionary Biology

    Reconstructing the functions of endosymbiotic Mollicutes in fungus-growing ants

    Panagiotis Sapountzis, Mariya Zhukova ... Jacobus J Boomsma
    Domestication of endosymbiotic Mollicutes may have resolved nitrogen-recycling challenges for attine ants and enabled the evolutionary derived leaf-cutting ants to fully exploit their herbivorous niches.
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology

    Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan

    Tao-Hsin Chang, Fu-Lien Hsieh ... E Yvonne Jones
    The crystal structure of Norrie Disease Protein in complex with the extracellular cysteine-rich domain of Frizzled4 receptor and sucrose octasulfate reveals binding sites for Frizzled4, low density lipoprotein receptor related protein 5/6, and proteoglycan.
    1. Neuroscience

    The landscape of regulatory genes in brain-wide neuronal phenotypes of a vertebrate brain

    Hui Zhang, Haifang Wang ... Jie He
    Single-cell transcriptomes of larval zebrafish whole brain shed light on the multidimensional landscapes of transcription factors and post-transcriptional regulators in vertebrate whole-brain neuronal classification and revealed principles of how neuronal cell diversity develops and evolves.
    1. Cell Biology
    2. Cancer Biology

    miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway

    Taichi Isobe, Shigeo Hisamori ... Yohei Shimono
    Insights into the roles and mechanisms of two of the miRNAs upregulated in human breast cancer stem cells in at least some breast cancers are presented.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis

    Liang Ge, David Melville ... Randy Schekman
    A cell-free biochemical assay for protein lipidation identifies the ER–Golgi intermediate compartment as a key early station in the formation of an autophagosome.
    1. Neuroscience

    Whole brain correlates of individual differences in skin conductance responses during discriminative fear conditioning to social cues

    Kevin Vinberg, Jörgen Rosén ... Fredrik Ahs
    A whole brain analysis using human neuroimaging data shows neural correlates of individual differences in conditioned fear.
    1. Neuroscience

    The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice

    Cristina Segalin, Jalani Williams ... Ann Kennedy
    The Mouse Action Recognition System is a computational pipeline for automated classification of social behaviors in freely interacting mice, accompanied by a graphical interface for analysis of multimodal neuroscience datasets.