4,464 results found
    1. Stem Cells and Regenerative Medicine

    Paracrine Met signaling triggers epithelial–mesenchymal transition in mammary luminal progenitors, affecting their fate

    Amandine Di-Cicco, Valérie Petit ... Marie-Ange Deugnier
    Mammary progenitors identified by a new marker, ICAM-1, undergo epithelial-mesenchymal transition and luminal-to-basal switch in response to paracrine Met activation.
    1. Chromosomes and Gene Expression

    Transcription factor condensates, 3D clustering, and gene expression enhancement of the MET regulon

    James Lee, Leman Simpson ... Lu Bai
    The condensates of activator Met4 are associated with 3D clustering of the MET regulon and its enhanced expression.
    1. Neuroscience

    Obtaining and maintaining cortical hand representation as evidenced from acquired and congenital handlessness

    Daan B Wesselink, Fiona MZ van den Heiligenberg ... Tamar R Makin
    fMRI results show that despite arm amputation, and varying degrees of phantom sensations, canonical hand representation in primary somatosensory cortex is largely maintained.
    1. Cell Biology

    A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling

    Minseong Kim, Carmen Reinhard, Christof Niehrs
    HGF-MET signaling phosphorylates- and PTPRK dephosphorylates ZNRF3 to regulate ZNRF3 internalization, functioning as a rheostat for Wnt signaling.
    1. Developmental Biology

    Met and Cxcr4 cooperate to protect skeletal muscle stem cells against inflammation-induced damage during regeneration

    Ines Lahmann, Joscha Griger ... Carmen Birchmeier
    Met and Cxcr4 signaling protects muscle stem cells from the noxious environment during acute inflammation.
    1. Neuroscience

    Focal optogenetic suppression in macaque area MT biases direction discrimination and decision confidence, but only transiently

    Christopher R Fetsch, Naomi N Odean ... Michael N Shadlen
    Perceptual decision making in monkeys can be manipulated by using optogenetics to inactivate functional subregions of visual cortex, but the brain has a capacity to compensate for this perturbation.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Siglec receptors impact mammalian lifespan by modulating oxidative stress

    Flavio Schwarz, Oliver MT Pearce ... Pascal Gagneux
    By contributing to the maintenance of ROS homeostasis, CD33-related Siglecs control oxidative damage and influence rate of aging and lifespan.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission

    Dawn M Wenzel, Douglas R Mackay ... Wesley I Sundquist
    A comprehensive, quantitative, protein-protein interaction screen maps the network of interactions between human MIT domains and ESCRT-III C-terminal tails, and reveals MIT domain-containing protein cofactors for abscission and the 'No Cut' abscission checkpoint.
    1. Cancer Biology

    Replication Study: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

    Jeewon Kim, Amirali Afshari ... Reproducibility Project: Cancer Biology
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but other parts could not be interpreted.

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