62 results found
    1. Genetics and Genomics
    2. Evolutionary Biology

    Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals

    Zane Kliesmete, Lucas Esteban Wange ... Wolfgang Enard
    Combining phylogenetic and functional approaches, it is shown that the protein sequence, the proliferative activity, and a regulatory element of TRNP1 co-evolve with brain size and folding.
    1. Neuroscience

    Striatal action-value neurons reconsidered

    Lotem Elber-Dorozko, Yonatan Loewenstein
    The numerous reports in support of action-value representation in the striatum are based on statistical analyses that are subject to two critical confounds and, thus, this long-held belief of striatal action-value representation should be retested using different experiments and analyses.
    1. Neuroscience

    Minimally dependent activity subspaces for working memory and motor preparation in the lateral prefrontal cortex

    Cheng Tang, Roger Herikstad ... Shih-Cheng Yen
    The evidence of subspace computation in the lateral prefrontal cortex provides insights into the neural mechanisms underlying cognitive flexibility and interference between different cognitive processes.
    1. Neuroscience

    Hierarchical temporal prediction captures motion processing along the visual pathway

    Yosef Singer, Luke Taylor ... Nicol S Harper
    Neural network modeling shows that hierarchical application of the simple computational principle of predicting future sensory input from its past can capture features of visual motion processing from the retina to the visual cortex.
    1. Immunology and Inflammation

    Modelling the response to vaccine in non-human primates to define SARS-CoV-2 mechanistic correlates of protection

    Marie Alexandre, Romain Marlin ... Rodolphe Thiébaut
    A model-based approach for modelling the immune control of viral dynamics is applied to quantify the effect of several SARS-CoV-2 vaccine platforms and to define mechanistic correlates of protection.
    1. Neuroscience

    Predictably manipulating photoreceptor light responses to reveal their role in downstream visual responses

    Qiang Chen, Norianne T Ingram ... Fred Rieke
    Quantitative models for responses of rod and cone photoreceptors are developed that allow direct tests of the impact of the photoreceptors on responses of downstream visual neurons.
    1. Genetics and Genomics

    Allele-specific gene-editing approach for vision loss restoration in RHO-associated retinitis pigmentosa

    Xiaozhen Liu, Jing Qiao ... Liping Yang
    The allele-specific gene-editing drug is expected to make RHO-T17M-associated retinitis pigmentosa therapy a reality.
    1. Neuroscience

    Persistent neural activity in auditory cortex is related to auditory working memory in humans and nonhuman primates

    Ying Huang, Artur Matysiak ... Michael Brosch
    The auditory cortex temporarily stores task-relevant information by persistently changed neuronal activity of single neurons and of neuronal populations.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Recombinant origin and interspecies transmission of a HERV-K(HML-2)-related primate retrovirus with a novel RNA transport element

    Zachary H Williams, Alvaro Dafonte Imedio ... Welkin E Johnson
    The genetic 'fossil record' of a retroviral lineage over >25 million years of evolution reveals the profound consequences of an ancient recombination event on viral replication mechanisms and genome structure, and identifies an ancient interspecies viral transmission.
    1. Neuroscience

    Coding strategies in the otolith system differ for translational head motion vs. static orientation relative to gravity

    Mohsen Jamali, Jerome Carriot ... Kathleen E Cullen
    Through different coding strategies, irregular and regular otolith afferents preferentially encode translational self-motion and changes in static head orientation relative to gravity.

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