Genomic imprinting in the bryophyte Marchantia polymorpha by Polycomb results in maternal dominance of embryonic gene expression.

The acquisition of cytotoxic function by human CD4 T cells is an integral part of the T helper 1 differentiation pathway and is limited by the transcription factor ThPOK.

Regulatory evolution allows paralogs to escape from strucural pleiotropy.

Engagement of both host and parasite signaling pathways proves a novel approach for developing improved anti-parasitic therapies.

Gamete-derived three-amino-acid-loop-extension homeodomain proteins activate zygote development in a strikingly similar manner between basal land plants and green algae, indicating an ancestral role of these transcription factors in green plants.

The anterior insula cortex is a critical neural substrate of context-induced relapse of nicotine-seeking.

Size threshold and suprastructure formation are key parameters that control the infective potential of amyloid fibrils as prion particles.

The ancestral mechanism to activate diploid gene expression via homeodomain transcription factors was retained in liverworts, an early diverging land plant lineage, and subsequently co-opted during evolution of the diploid sporophyte body.

An ancient and conserved genetic mechanism for cell differentiation is under distinct negative regulation in different lineages of land plants.

Analysis of the Arabidopsis V-ATPase reveals convergent evolution of differential targeting as well as redundancy of the endosomal and vacuolar isoforms during vegetative development.