126 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Histone supply regulates S phase timing and cell cycle progression

    Ufuk Günesdogan, Herbert Jäckle, Alf Herzig
    Controlling cell cycle progression in a developing embryo directly depends on de novo histone supply and a specialized surveillance mechanism for nucleosome assembly.
    1. Neuroscience

    Filopodial dynamics and growth cone stabilization in Drosophila visual circuit development

    Mehmet Neset Özel, Marion Langen ... P Robin Hiesinger
    Long-term live imaging in intact developing Drosophila brains reveals a role for N-Cadherin-mediated fast filopodial dynamics and growth cone stabilization during neural circuit assembly.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions

    Benjamin P Bouchet, Rosemarie E Gough ... Anna Akhmanova
    Interactions between talin1 and a cortical scaffolding protein KANK1 control microtubule stabilization in the vicinity of focal adhesions.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda

    François Blanquart, Mary Kate Grabowski ... Christophe Fraser
    Analysis of epidemiological data reveals that viral loads in newly HIV-1 infected individuals in Uganda have declined for two decades, and evolutionary modelling shows that attenuation of the virus explains this decline.
    1. Biochemistry and Chemical Biology

    Total biosynthesis of the cyclic AMP booster forskolin from Coleus forskohlii

    Irini Pateraki, Johan Andersen-Ranberg ... Björn Hamberger
    The entire biosynthetic pathway for the diterpenoid forskolin in Coleus forskohlii has been reconstituted in yeast.
    1. Neuroscience

    An inhibitory gate for state transition in cortex

    Stefano Zucca, Giulia D’Urso ... Tommaso Fellin
    Two major subtypes of cortical interneurons, the PV and the SST positive cells, causally contribute to the regulation of large-scale state transitions in the cortex.
    1. Biochemistry and Chemical Biology

    Serine ADP-ribosylation reversal by the hydrolase ARH3

    Pietro Fontana, Juan José Bonfiglio ... Ivan Ahel
    ARH3 is an enzyme that hydrolyses serine ADP-ribosylation, a recently uncovered post-translational protein modification.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamics of genomic innovation in the unicellular ancestry of animals

    Xavier Grau-Bové, Guifré Torruella ... Iñaki Ruiz-Trillo
    The foundations of genomic complexity in multicellular animals have deep roots in their unicellular prehistory, both in terms of innovations in gene content, as well as the evolutionary dynamics of genome architecture.
    1. Ecology

    Cyclic bouts of extreme bradycardia counteract the high metabolism of frugivorous bats

    M Teague O'Mara, Martin Wikelski ... Dina KN Dechmann
    Novel heart rate strategies that minimize energy expenditure during the day are necessary to cope with high energy nocturnal lifestyles of tent-making bats.
    1. Ecology
    2. Evolutionary Biology

    Dynamics of venom composition across a complex life cycle

    Yaara Y Columbus-Shenkar, Maria Y Sachkova ... Yehu Moran
    Different developmental stages of a venomous animal (e.g. Nematostella vectensis) with a complex life cycle produce vastly different venoms that can serve in different antagonistic interactions with other species.

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