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    1. Cell Biology
    2. Microbiology and Infectious Disease

    High-content high-resolution microscopy and deep learning assisted analysis reveals host and bacterial heterogeneity during Shigella infection

    Ana T. López-Jiménez, Dominik Brokatzky ... Serge Mostowy
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    1. Cell Biology

    Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells

    Vincenza Caolo, Marjolaine Debant ... David J Beech
    Cell protease and cell fate decisions are regulated by a bone fide force-sensor, the Piezo1 channel, and by this means achieve integration with the mechanical environment.
    1. Neuroscience

    LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses

    Alessandra Sclip, Thomas C Südhof
    LAR-RPTPs are not essential for synapse formation, but they are important determinants of synapse properties as they contribute to regulate postsynaptic NMDA receptor function.
    1. Immunology and Inflammation
    2. Medicine

    Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273

    Niels JM Verstegen, Ruth R Hagen ... Carolien E van de Sandt
    SARS-CoV-2 experienced ocrelizumab-treated MS patients benefit from SARS-CoV-2 mRNA vaccination by inducing broadprotective CD8+ T-cells, whereas methotrexate-treated RA patients induce delayed but strong antibody responses, which support vaccine strategies for these patient groups.
    1. Computational and Systems Biology
    2. Medicine

    Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats

    Hong Yang, Cheng Zhang ... Adil Mardinoglu
    Inhibiting c-Jun N-terminal kinase exerts a cross-tissue therapeutic effect on metabolic dysfunction induced by sucrose overconsumption in rats.
    1. Neuroscience

    The impact of bilateral ongoing activity on evoked responses in mouse cortex

    Daisuke Shimaoka, Nicholas A Steinmetz ... Matteo Carandini
    Spontaneous bilateral fluctuations add with evoked cortical activity and explain much of the variability in sensory responses.
    1. Cancer Biology

    Lipid droplets and ferritin heavy chain: a devilish liaison in human cancer cell radioresistance

    Luca Tirinato, Maria Grazia Marafioti ... Joao Seco
    Lipid Droplet accumulation is a fingerprint shared by different human cancer radioresistant cells and their biogenesis strongly depend on FTH1 presence.
    1. Neuroscience

    Visuo-motor updating in individuals with heightened autistic traits

    Antonella Pomè, Eckart Zimmermann
    Efference copy dysfunctions in heightened autistic traits impair the use of eye movement information for spatial representation and object localization.
    1. Medicine

    Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling

    Joseph D Butner, Geoffrey V Martin ... Vittorio Cristini
    A mechanistic mathematical model informed by standard‐of‐care imaging and pathology predicts tumor responses to immunotherapy a priori on a per-patient basis.
    1. Neuroscience

    Double-μPeriscope, a tool for multilayer optical recordings, optogenetic stimulations or both

    Mototaka Suzuki, Jaan Aru, Matthew E Larkum
    Interactions between near but distinct (<1 mm) structures such as cortical layers in the rodent brain can be studied by a new micro-optical tool that is low-cost and capable of multilayer optical recordings, optogenetic stimulations, or both.