5,903 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Conformational distributions of isolated myosin motor domains encode their mechanochemical properties

    Justin R Porter et al.
    Shifts in the balance between nucleotide-favorable and nucleotide-unfavorable conformations of myosin motors encode duty ratios and ADP release rates, demonstrating the power of an ensemble perspective for uncovering sequence-function relationships.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Linking time-series of single-molecule experiments with molecular dynamics simulations by machine learning

    Yasuhiro Matsunaga, Yuji Sugita
    A general machine learning scheme for integrating time-series data from single-molecule experiments and molecular dynamics simulations is proposed and successfully demonstrated for the folding dynamics of the WW domain.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Simulation of spontaneous G protein activation reveals a new intermediate driving GDP unbinding

    Xianqiang Sun et al.
    Combining powerful simulation methods uncovers the structural and dynamical changes driving G protein activation in atomic detail, revealing the allosteric network that triggers GDP release and reconciling diverse experimental data.
    1. Computational and Systems Biology
    2. Developmental Biology

    Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18

    Huan Liu et al.
    Analysis of zebrafish periderm enhancers illuminates the conserved DNA of epithelial enhancers across species and prioritizes orofacial-cleft-associated regulatory variants near KRT18/KRT8.
    1. Neuroscience

    Statistical structure of locomotion and its modulation by odors

    Liangyu Tao et al.
    A fly's locomotion can be decomposed into a small number of locomotor features which can be modulated by odors and other sensory information.
    1. Chromosomes and Gene Expression

    Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

    Daan Noordermeer et al.
    Hox genes are activated sequentially and, at the same time, undergo a transition from an inactive to an active chromatin compartment, most likely to prevent posterior genes being activated too early.
    1. Neuroscience

    Coordination of rapid cholinergic and dopaminergic signaling in striatum during spontaneous movement

    Mark Howe et al.
    Optical recordings reveal previously unknown neuromodulator dynamics in the striatum during animal movements that suggest a new interpretation of the underpinnings of bradykinetic movements exhibited in Parkinson's Disease patients.
    1. Chromosomes and Gene Expression
    2. Stem Cells and Regenerative Medicine

    TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2

    Rosa María Marión et al.
    Telomeric TRF1 controls the transcriptional programmes of pluripotent stem cells by recruiting PRC2 to pluripotency and differentiation genes by controlling the expression of those gene sites and the binding of TERRA RNAs to them.
    1. Biochemistry and Chemical Biology

    The dynamic conformational landscape of the protein methyltransferase SETD8

    Shi Chen et al.
    Integrated experimental-computational approaches were implemented to reveal the dynamic conformational landscape of a biologically relevant protein methyltransferase SETD8 for functional annotation.
    1. Structural Biology and Molecular Biophysics

    Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

    Cristina Olivieri et al.
    A combination of NMR, fluorescence, and molecular dynamics simulations reveals the recognition mechanism for the intrinsically disordered regulator of protein kinase A, highlighting the enzyme's nuclear export process.

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