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Immunology and Inflammation
IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate
Mark Noviski et al.
Self-reactive B cells downregulate the IgM but not the IgD B cell receptor, and this serves as a critical tolerance mechanism because IgD is less sensitive to bona fide endogenous antigens than IgM.
Early intrinsic hyperexcitability does not contribute to motoneuron degeneration in amyotrophic lateral sclerosis
Félix Leroy et al.
Contrary to a long-standing hypothesis, the neuronal death that leads to muscle wastage in amyotrophic lateral sclerosis does not result from overactivity of those neurons during development.
Computational and Systems Biology
Inference of gene regulation functions from dynamic transcriptome data
Patrick Hillenbrand et al.
Quantitative analysis of time-dependent transcription data elucidates the signal processing within the genetic network that regulates transcriptional cell cycle oscillations in yeast.
Biochemistry and Chemical Biology
Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling
Rajan Thakur et al.
Phosphatidic acid regulates recycling of endocytosed plasma membrane vesicles in polarized cells through a retromer and Arf1 dependent process.
Selective sorting and destruction of mitochondrial membrane proteins in aged yeast
Adam L Hughes et al.
A new mitochondrial protein degradation pathway selectively sorts and destroys a subset of the mitochondrial membrane proteome to protect mitochondria in times of stress.
Recruitment of inhibition and excitation across mouse visual cortex depends on the hierarchy of interconnecting areas
Rinaldo David D'Souza et al.
The relative recruitment of excitatory and inhibitory neurons by cortico-cortical interareal pathways depends on the hierarchy of areas and the laminar location of the neurons.
Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons
Farid N Garas et al.
In rodents and primates, there are two subtypes of parvalbumin-expressing interneurons that provide novel substrates for selective inhibition in the striatum.
Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo
Peter James Morgan et al.
Short, theta-bursts of action potential firing decrease the global excitability of CA1 pyramidal neurons, providing an internal mechanism which could regulate their allocation to memory engrams.
Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb
Luis Sánchez-Guardado, Carlos Lois
Sister projection neurons in the mammalian olfactory system do not share sensory synaptic input indicating that lineage-independent mechanisms regulate their synaptic connectivity with the olfactory sensory neurons.
Genetics and Genomics
A de novo evolved gene in the house mouse regulates female pregnancy cycles
Chen Xie et al.
A female specifically expressed new protein-coding gene that has emerged out of non-coding sequences without detectable signatures of adaptive evolution affects female pregnancy cycles.
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