513 results found
    1. Biochemistry and Chemical Biology

    The molecular coupling between substrate recognition and ATP turnover in a AAA+ hexameric helicase loader

    Neha Puri et al.
    Structure-guided biochemistry defines how the coupling between nucleic acid substrate binding and ATPase activity is used by a molecular switch to load ring-shaped motor proteins onto single-stranded DNA.
    1. Developmental Biology
    2. Evolutionary Biology

    Early maternal loss leads to short- but not long-term effects on diurnal cortisol slopes in wild chimpanzees

    Cédric Girard-Buttoz et al.
    Wild chimpanzees contrast to humans since adult male chimpanzees do not exhibit physiological indicators of biological embedding of the stress associated to maternal loss early in life.
    1. Ecology
    2. Plant Biology

    Genetic variation, environment and demography intersect to shape Arabidopsis defense metabolite variation across Europe

    Ella Katz et al.
    Measurements of specialized metabolites across a population of 800 natural Arabidopsis thaliana accessions revealed different pressures and evolutionary processes that shaped their variation and distribution across Europe.
    1. Evolutionary Biology

    Myoglobin primary structure reveals multiple convergent transitions to semi-aquatic life in the world's smallest mammalian divers

    Kai He et al.
    Ancestral sequence reconstruction of an essential muscle protein involved in oxygen storage and transport accurately tracks secondary aquatic transitions in a speciose clade of insectivorous mammals.
    1. Epidemiology and Global Health

    High infectiousness immediately before COVID-19 symptom onset highlights the importance of continued contact tracing

    William S Hart et al.
    Fitting a mechanistic model to data from SARS-CoV-2 source-recipient pairs generates improved estimates of changes in infectiousness during infection, indicating substantial transmission shortly before symptom onset.
    1. Developmental Biology

    Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations

    Wenqing Li et al.
    Genetic studies reveal that mosaic inactivation of ccm2 causes characteristic cerebral cavernous malformations in adult zebrafish and aberrant responses to blood flow that induce the formation of a lethal embryonic multi-cavernous venous malformation.
    1. Evolutionary Biology

    Rampant tooth loss across 200 million years of frog evolution

    Daniel J Paluh et al.
    Teeth are maintained in two amphibian groups (caecilians and salamanders) but were lost in frogs over 20 times independently, a higher incidence of edentulism than any other major vertebrate group.
    1. Medicine

    Miniaturized 3D bone marrow tissue model to assess response to Thrombopoietin-receptor agonists in patients

    Christian A Di Buduo et al.
    A 3D bone marrow niche that reproduces megakaryocyte differentiation and ex vivo platelet production from hematopoietic progenitors and iPSCs of thrombocytopenic patients predicts individual response to Eltrombopag accurately.
    1. Neuroscience

    Perturbation of amygdala-cortical projections reduces ensemble coherence of palatability coding in gustatory cortex

    Jian-You Lin et al.
    Blocking input from basolateral amygdala to gustatory cortex (GC) severely reduces the coherence of GC ensemble activity, which negatively affects epochal dynamics involved in driving palatability-driven consumption.
    1. Cancer Biology
    2. Genetics and Genomics

    Endogenous p53 expression in human and mouse is not regulated by its 3′UTR

    Sibylle Mitschka, Christine Mayr
    The endogenous 3′UTR does not regulate TP53 mRNA or protein level and the 3′UTR is repressive when used alone in reporters, but addition of the coding region has a dominant repressive effect.

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