72 results found
    1. Structural Biology and Molecular Biophysics

    Distinct expression requirements and rescue strategies for BEST1 loss- and gain-of-function mutations

    Qingqing Zhao et al.
    BEST1 autosomal dominant loss-of-function mutations surprisingly behave in a dominant-negative manner, whereas gain-of-function mutations exhibit a strong dominant effect that necessitates CRISPR/Cas9-mediated suppression of the endogenous mutant allele in gene therapy.
    1. Neuroscience

    Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner

    Kang-Ying Qian et al.
    Male pheromone environment increases the cholinergic synaptic transmission at the neuromuscular junction in Caenorhabditis elegans hermaphrodites during development, decreasing hermaphrodites' locomotion activity and promoting mating efficiency.
    1. Immunology and Inflammation

    Seroconversion stages COVID19 into distinct pathophysiological states

    Matthew D Galbraith et al.
    Stratification of COVID19 patients using quantitative metrics of seroconversion reveals distinct pathophysiological stages after SARS-CoV-2 infection, including key differences in immune cell types, inflammatory makers, and markers of organ function.
    1. Computational and Systems Biology

    DIPPER, a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics

    Vivian Tam et al.
    Deep and comprehensive proteomic resource of human intervertebral disc at high spatial resolution with a methodological flow reveals new insights in disc homeostasis and degeneration.
    1. Neuroscience

    Deleting Mecp2 from the cerebellum rather than its neuronal subtypes causes a delay in motor learning in mice

    Nathan P Achilly et al.
    The loss of Mecp2 results in cerebellar dysfunction that contributes to the motor deficits in Rett syndrome.
    1. Developmental Biology

    Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function

    Matthew J Anderson et al.
    Quantification of fluorescently labeled mRNAs reveals that Fgf4 regulates Notch oscillations in the segmentation clock that controls somitogenesis.
    1. Developmental Biology
    2. Neuroscience

    Leptin suppresses development of GLP-1 inputs to the paraventricular nucleus of the hypothalamus

    Jessica E Biddinger et al.
    Leptin acts cell autonomously on brainstem neurons that express GLP-1 to suppress development of excitatory viscerosensory inputs to the hypothalamus.
    1. Neuroscience

    Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior

    Sthitapranjya Pati et al.
    Enhanced Gq-signaling-mediated activation of forebrain excitatory neurons in postnatal life programs enhanced anxiety-, despair- and schizophrenia-like behavior, recapitulating key aspects of the behavioral consequences of early life adversity.
    1. Developmental Biology

    Geometric models for robust encoding of dynamical information into embryonic patterns

    Laurent Jutras-Dubé et al.
    Propagation, speed and shapes of genetic waves of expression during development can be modeled by a simple interplay between two transcriptional modules (dynamic/static), which explains robustness and precision of patterning.
    1. Cell Biology

    Complementary α-arrestin-ubiquitin ligase complexes control nutrient transporter endocytosis in response to amino acids

    Vasyl Ivashov et al.
    Metabolic cues enlist ubiquitin ligase adaptors for the selective control of cellular nutrient acquisition strategies.

Refine your results by:

Type
Research categories