Müller glia cells in the medaka (Oryzias latipes) retina act as lineage restricted progenitors which only regenerate photoreceptors but can be activated to perform as potent stem cells using Sox2.
Erika Tsingos, Burkhard Höckendorf ... Joachim Wittbrodt
3D niche topology imposes a spatially biased random stem cell loss, which is differentially fine-tuned in neural retina and retinal pigmented epithelium to regulate growth, shape, and cellular topology.
Luisa F Arias Padilla, Diana C Castañeda-Cortés ... Juan I Fernandino
In medaka fish, the reduction of cystic proliferation of germ stem cells declines gametogenesis, reproduction success, and male sexual behavior, with a decrease of mating vigor.
Jose Arturo Gutierrez-Triana, Tinatini Tavhelidse ... Joachim Wittbrodt
The 5' modification of the donor template facilitates highly efficient Crispr targeted homologous recombination and at the same time favors single copy integration.
In medaka fish, galanin-expressing neurons in the medial preoptic area occur nearly exclusively in males and mediate androgen-dependent male–male aggressive chases.