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    1. Developmental Biology

    Functional genome-wide siRNA screen identifies KIAA0586 as mutated in Joubert syndrome

    Susanne Roosing, Matan Hofree ... Joseph G Gleeson
    A supervised learning approach on a high-content genome-wide siRNA screen has identified 591 likely candidates for ciliopathies and facilitated in the discovery of KIAA0586 mutations in individuals with Joubert syndrome.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Eighteenth century Yersinia pestis genomes reveal the long-term persistence of an historical plague focus

    Kirsten I Bos, Alexander Herbig ... Hendrik N Poinar
    The analysis of 18th century Y. pestis genomes reveals a bacterial lineage that might be responsible for the 400-year period of European plague epidemics from the Renaissance through early modern times.
    1. Evolutionary Biology

    Evolutionary footprints of a cold relic in a rapidly warming world

    Eva Wolf, Emmanuel Gaquerel ... Marcus A Koch
    Evolutionary dynamics of polyploid plants of the genus Cochlearia during past periods of rapid climate change indicate increased rates of speciation and diversification in response to pronounced glacial cycles and cold periods in particular.
    1. Cancer Biology
    2. Ecology

    Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe

    Daniel Garcia-Souto, Alicia L Bruzos ... Jose MC Tubio
    Genome sequencing analysis dissects the origins and evolution of cancer transmission between clam species in the Seas of Southern Europe.
    1. Ecology
    2. Evolutionary Biology

    Desiccation resistance differences in Drosophila species can be largely explained by variations in cuticular hydrocarbons

    Zinan Wang, Joseph P Receveur ... Henry Chung
    Evolutionary changes in cuticular hydrocarbons, a lipid layer on the insect epicuticle, underlie the evolution of desiccation resistance in Drosophila species.
    1. Ecology

    A small number of workers with specific personality traits perform tool use in ants

    István Maák, Garyk Roelandt, Patrizia d'Ettorre
    The likelihood to perform tool use during foraging is linked to personality traits in ants, suggesting an original interplay between consistent inter-individual variability and division of labor in social species.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Bias in nutrition-health associations is not eliminated by excluding extreme reporters in empirical or simulation studies

    Nao Yamamoto, Keisuke Ejima ... Andrew W Brown
    Elimination of extreme reporters using Goldberg cutoffs does not always produce unbiased estimates of associations between nutrition intakes and health outcomes.
    1. Ecology
    2. Evolutionary Biology

    Thermal acclimation of tropical coral reef fishes to global heat waves

    Jacob L Johansen, Lauren E Nadler ... Jodie Rummer
    The ability of animals to adjust to thermal stress is critical for survival under global warming, yet the adjustment process and scope have (until now) remained obscure in marine fishes.
    1. Computational and Systems Biology

    Statistical and computational methods for integrating microbiome, host genomics, and metabolomics data

    Rebecca A Deek, Siyuan Ma ... Hongzhe Li
    Advanced statistical and computational methods are reviewed and compared for integrating microbiome, host genomics, and metabolomics data, together with future research directions.
    1. Ecology
    2. Neuroscience

    Combined transcriptome and proteome profiling reveals specific molecular brain signatures for sex, maturation and circalunar clock phase

    Sven Schenk, Stephanie C Bannister ... Kristin Tessmar-Raible
    A molecular profiling approach to quantify transcripts and proteins from identical samples allows study of molecular effects of maturation, sexual differentiation and the endogenous circalunar clock in a marine worm.