Susanne Roosing, Matan Hofree ... Joseph G Gleeson
A supervised learning approach on a high-content genome-wide siRNA screen has identified 591 likely candidates for ciliopathies and facilitated in the discovery of KIAA0586 mutations in individuals with Joubert syndrome.
Kirsten I Bos, Alexander Herbig ... Hendrik N Poinar
The analysis of 18th century Y. pestis genomes reveals a bacterial lineage that might be responsible for the 400-year period of European plague epidemics from the Renaissance through early modern times.
Evolutionary dynamics of polyploid plants of the genus Cochlearia during past periods of rapid climate change indicate increased rates of speciation and diversification in response to pronounced glacial cycles and cold periods in particular.
Evolutionary changes in cuticular hydrocarbons, a lipid layer on the insect epicuticle, underlie the evolution of desiccation resistance in Drosophila species.
The likelihood to perform tool use during foraging is linked to personality traits in ants, suggesting an original interplay between consistent inter-individual variability and division of labor in social species.
Elimination of extreme reporters using Goldberg cutoffs does not always produce unbiased estimates of associations between nutrition intakes and health outcomes.
Jacob L Johansen, Lauren E Nadler ... Jodie Rummer
The ability of animals to adjust to thermal stress is critical for survival under global warming, yet the adjustment process and scope have (until now) remained obscure in marine fishes.
Advanced statistical and computational methods are reviewed and compared for integrating microbiome, host genomics, and metabolomics data, together with future research directions.
Sven Schenk, Stephanie C Bannister ... Kristin Tessmar-Raible
A molecular profiling approach to quantify transcripts and proteins from identical samples allows study of molecular effects of maturation, sexual differentiation and the endogenous circalunar clock in a marine worm.