32 results found
    1. Epidemiology and Global Health

    Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health

    Neil Martin Davies et al.
    Many of the effects of intelligence on health and social outcomes later in life are mediated via education.
    1. Genetics and Genomics
    2. Medicine

    Effects of lifelong testosterone exposure on health and disease using Mendelian randomization

    Pedrum Mohammadi-Shemirani et al.
    Long-term increased testosterone improved body composition and bone density, but lowered HDL and raised risks of hypertension, androgenic alopecia, prostate cancer, and spinal stenosis in males.
    1. Genetics and Genomics

    Integration of genomics and transcriptomics predicts diabetic retinopathy susceptibility genes

    Andrew D Skol et al.
    Integrating gene expression with genetic association data provided insights into the functional relevance of genetic risk for a complex disease, thus implicating folliculin as a putative diabetic retinopathy susceptibility gene.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Predicting the effect of statins on cancer risk using genetic variants from a Mendelian randomization study in the UK Biobank

    Paul Carter et al.
    Genetic evidence in humans suggests that statins reduce cancer risk via a cholesterol-independent pathway.
    1. Computational and Systems Biology

    The MR-Base platform supports systematic causal inference across the human phenome

    Gibran Hemani et al.
    Compiling public datasets into a single, centralised repository and linking directly to analytical software completely transforms the scale and scope of causal inference across the phenome.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation

    CM Schooling et al.
    Identifying why statins differ from other major lipid modifiers has revealed a new modifiable target of intervention for cardiovascular disease relevant to both drug development and optimal statin use.
    1. Genetics and Genomics

    An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

    Tom G Richardson et al.
    A resource to systematically explore the association between overall genetic risk for 162 risk factors and disease with 551 outcomes.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Plasma proteomic biomarker signature of age predicts health and life span

    Toshiko Tanaka et al.
    Analysis of proteomic data identified protein biomarkers of aging, mortality and aging-related diseases, supporting their use to monitor aging trajectories and identify individuals at higher risk of disease.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Co-expression analysis reveals interpretable gene modules controlled by trans-acting genetic variants

    Liis Kolberg et al.
    Co-expression analysis combined with functional enrichment improves the detection and prioritisation of trans-eQTLs when applied to emerging cell-type-specific datasets.
    1. Genetics and Genomics

    Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes

    David A Knowles et al.
    Genetic variants that modulate transcriptomic response to doxorubicin in human iPSC-derived cardiomyocytes are predictive of cardiac damage and in vivo sensitivity to anthracycline cardiotoxicity.

Refine your results by:

Type
Research categories