120 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM

    Valeria Kalienkova et al.
    cryo-EM reveals the properties of distinct conformations occupied during activation of the lipid scramblase nhTMEM16 and provides new insights into its interactions with the lipid environment.
    1. Structural Biology and Molecular Biophysics

    Structure and mechanism of the Mrp complex, an ancient cation/proton antiporter

    Julia Steiner, Leonid Sazanov
    Structure of the Mrp antiporter, an ancestor of respiratory complex I, suggests a mechanism of coupling between cation and proton translocation, applicable to a large family of related membrane proteins.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Chromosome organization by one-sided and two-sided loop extrusion

    Edward J Banigan et al.
    Seemingly contradictory findings of single-molecule and in vivo experiments on a major mechanism of chromosome organization are reconciled by computationally investigating mechanisms of loop extrusion that are consistent with both.
    1. Cancer Biology

    Mutationally-activated PI3’-kinase-α promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase

    J Edward van Veen et al.
    Two of the most commonly mutated growth factor pathways induce a deadly feature of lung adenocarcinoma.
    1. Cell Biology
    2. Developmental Biology

    Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance

    Mannu K Walia et al.
    The loss of p53 in bone cells activates critical signaling pathways; these are also essential in bone cancer.
    1. Cell Biology
    2. Cancer Biology

    BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function

    Xuetian Yue et al.
    Overexpression of BAG2—a novel mutant p53 binding protein—in tumors inhibits MDM2-mediated mutant p53 degradation, which leads to the accumulation of mutant p53 protein and promotes tumorigenesis.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dissecting the DNA binding landscape and gene regulatory network of p63 and p53

    Konstantin Riege et al.
    A resource of p63-regulated genes, genomic loci bound by p63, p63 DNA recognition motifs, and potential co-factors is generated through a meta-analysis of high-throughput datasets.
    1. Developmental Biology
    2. Genetics and Genomics

    OTX2 represses sister cell fate choices in the developing retina to promote photoreceptor specification

    Miruna Georgiana Ghinia Tegla et al.
    A retinal gene regulatory network prevents the formation of alternative cell fates from non-stochastic retinal progenitor cells.
    1. Chromosomes and Gene Expression

    Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity

    Jeffrey M Alexander et al.
    Sox2 transcription is not correlated with spatial proximity of its essential regulatory enhancer in embryonic stem cells, suggesting gene transcription is not limited to periods of direct enhancer-promoter contact.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Dissection of zebrafish shha function using site-specific targeting with a Cre-dependent genetic switch

    Kotaro Sugimoto et al.
    A versatile invertible gene trap vector is generated and inserted into a defined genomic locus in zebrafish via homologous recombination, demonstrating an efficient genetic approach to performing conditional knockout analysis.

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