264 results found
    1. Developmental Biology
    2. Genetics and Genomics

    Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network

    Yamila N Torres Cleuren et al.
    Quantitative genetic analyses reveal remarkably broad genetic variation underlies the requirement for two critical regulatory inputs into a core embryonic gene regulatory network within one animal species.
    1. Developmental Biology
    2. Evolutionary Biology

    Fgf-signaling is compartmentalized within the mesenchyme and controls proliferation during salamander limb development

    Sruthi Purushothaman et al.
    While movement of Fgf-signaling to the limb mesenchyme accompanied a shift in function, the ultimate outcome remains a convergent tetrapod limb phenotype.
    1. Developmental Biology
    2. Evolutionary Biology

    A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle

    Glenda Comai et al.
    Tbx1-Isl1-Met defines a unique genetic hierarchy that regulates esophagus myogenesis and patterning in the mouse.
    1. Cell Biology
    2. Developmental Biology

    Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration

    Lu Wei et al.
    Notch signaling controls the collective migration of parapineal cells through its capacity to restrict FGF pathway activation to a few leading cells.
    1. Developmental Biology

    Cardiac neural crest contributes to cardiomyocytes in amniotes and heart regeneration in zebrafish

    Weiyi Tang et al.
    Lineage analysis reveals that cardiac neural crest contributes to cardiomyocytes across vertebrates and consistent with this, the neural crest gene regulatory program is reactivated upon heart regeneration in zebrafish.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice

    Yuyong Tao et al.
    Modular tetravalent antibodies can be engineered to stimulate signaling through any combination of Frizzled and LRP receptors to drive organoid growth and mobilize endogenous stem cells in vivo.
    1. Developmental Biology

    Neural crest-specific deletion of Rbfox2 in mice leads to craniofacial abnormalities including cleft palate

    Dasan Mary Cibi et al.
    The identification of the splicing code and all the required components of alternative splicing will be crucial for a comprehensive understanding of this process in the neural crest cell biology.
    1. Developmental Biology

    Critical roles of ARHGAP36 as a signal transduction mediator of Shh pathway in lateral motor columnar specification

    Heejin Nam et al.
    Shh, produced by postmitotic spinal neurons, plays crucial roles in the specification of the lateral motor column of the spinal cord through ARHGAP36.
    1. Developmental Biology

    Single-cell sequencing of neonatal uterus reveals an Misr2+ endometrial progenitor indispensable for fertility

    Hatice Duygu Saatcioglu et al.
    Single-cell RNA sequencing of neonatal uterus revealed an Misr2+ endometrial stromal progenitor whose inhibition by ectopic administration of MIS caused uterine hypoplasia and infertility in adulthood.

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