Evolutionary loss of foot muscle in a bipedal rodent shares similarities with skeletal muscle atrophy, which is typically considered a pathological response to injury or disease.
Treatment of human pluripotent stem cell-derived myotubes with a cocktail of small molecules induces their maturation, as shown by gene expression, biochemical and functional assays.
An iterative self-assembling algorithm identifies the intrinsic structures in single-cell transcriptomic data and helps to discover new cell populations that are undetectable by existing methods.
FGFRs regulate multipolar cortical neuron orientation and the morphological change into bipolar cells in vivo under the control of N-Cadherin and the extracellular matrix protein Reelin.
Endogenous BMP2/7 and BMP4/7 heterodimers form in vivo, and are the predominant functional ligand in many, if not all, tissues of developing mouse embryos.
NEIL DNA glycosylases are required to counteract oxidative base damages within the mitochondrial genome to safeguard neural crest cell differentiation.
Quantitative genetic analyses reveal remarkably broad genetic variation underlies the requirement for two critical regulatory inputs into a core embryonic gene regulatory network within one animal species.
While movement of Fgf-signaling to the limb mesenchyme accompanied a shift in function, the ultimate outcome remains a convergent tetrapod limb phenotype.
