5,614 results found
    1. Genetics and Genomics

    Parallel CRISPR-Cas9 screens clarify impacts of p53 on screen performance

    Anne Ramsay Bowden et al.
    The protein p53 negatively impacts the ability of a CRISPR screen to discriminate between essential and non-essential genes, hence, p53 status should be considered in these screens.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Science Forum: Addressing selective reporting of experiments through predefined exclusion criteria

    Kleber Neves, Olavo B Amaral
    Researchers should define in advance the criteria for excluding the results of experiments that 'did not work' from articles.
    1. Neuroscience

    Auditory cortical alpha/beta desynchronization prioritizes the representation of memory items during a retention period

    Nathan Weisz et al.
    Top-down mediated decreases of beta activity in auditory cortex prior to a predictable distractor in an auditory working memory task is associated with increased representation of to-be-memorized information.
    1. Computational and Systems Biology
    2. Neuroscience

    The natverse, a versatile toolbox for combining and analysing neuroanatomical data

    Alexander Shakeel Bates et al.
    Open source software enables neuroscientists to integrate single neuron or synaptic-resolution datasets from different imaging modalities to analyse morphology and connectivity at the scale of whole brains and connectomes.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures and functional properties of CALHM channels of the human placenta

    Katarzyna Drożdżyk et al.
    Members of the calcium homeostasis modulator family expressed in the placenta form large channels with unknown activation properties that harbor a lipid bilayer on the inside of a cylindrical pore.
  1. eLife Latest: Supporting AllTrials to encourage the registration and reporting of all clinical trials

    AllTrials is calling for broad scrutiny to help uncover missing results from past clinical trials.
    1. Developmental Biology
    2. Neuroscience

    Temporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships

    Julia L Meng et al.
    Acting in neuronal stem cells, temporal transcription factors, as a class of molecules, are uniquely potent determinants of circuit membership that establish expected patterns of wiring in the motor system.
    1. Cell Biology

    Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion

    Julia Damiano-Guercio et al.
    Ena/VASP proteins act as positive regulators of cell motility and are required for the formation of microspikes, as opposed to filopodia that can arise from distinct molecular mechanisms.
    1. Neuroscience

    Synergistic actions of v-SNARE transmembrane domains and membrane-curvature modifying lipids in neurotransmitter release

    Madhurima Dhara et al.
    Naturally-occurring v-SNARE TMD variants differentially regulate fusion pore dynamics and cooperate with phospholipids in supporting membrane curvature at the fusion pore neck.

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