4,912 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1

    Xiaocheng Zhao et al.
    The cAMP-dependent protein kinase A controls the switch from actively sprouting new blood vessel formation to vessel quiescence by reducing endothelial autophagy through phosphorylation-mediated destabilisation of ATG16L1.
    1. Microbiology and Infectious Disease

    Sexual transmission of murine papillomavirus (MmuPV1) in Mus musculus

    Megan E Spurgeon, Paul F Lambert
    MmuPV1, a papillomavirus that infects laboratory mice (Mus musculus), is discovered to be sexually transmitted, providing a new animal virus model to study sexually transmitted human papillomaviruses (HPVs).
    1. Computational and Systems Biology
    2. Evolutionary Biology

    ASPEN, a methodology for reconstructing protein evolution with improved accuracy using ensemble models

    Roman Sloutsky, Kristen M Naegle
    Using different sets of input sequences to evolutionary reconstruction algorithms results in the exploration of many possible models, the intergration over which produces significantly more accurate models.
    1. Biochemistry and Chemical Biology

    Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics

    Shannon N Mostyn et al.
    Identification of how bioactive lipids bind and inhibit glycine transporters has the potential to be exploited in the development of a new class of analgesics for chronic pain.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Control of RNA viruses in mosquito cells through the acquisition of vDNA and endogenous viral elements

    Michel Tassetto et al.
    Virus infection in mosquitoes initiates a highly discriminatory process in which fragments of viral RNA are reverse transcribed to create DNA copies that serve as templates of small antiviral RNAs.
    1. Neuroscience

    During hippocampal inactivation, grid cells maintain synchrony, even when the grid pattern is lost

    Noam Almog et al.
    Grid cells lose their hexagonality during hippocampal inactivation, but maintain temporal and spatial synchrony between pairs of cells, implying that hippocampus does not determine phase relations between grid cells.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Dynamic turnover of centromeres drives karyotype evolution in Drosophila

    Ryan Bracewell et al.
    De novo formation of centromeres creates diverse karyotypes in flies and is accompanied by rapid turnover of centromere-associated satellite repeats.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis

    Andrey Poleshko et al.
    The histone modification H3K9me2 marks peripheral heterochromatin and ensures positional information is safeguarded through cell division such that individual lamina-associated domains are re-established at the nuclear periphery in daughter nuclei.
    1. Cell Biology
    2. Developmental Biology

    Matrix metalloproteinase 1 modulates invasive behavior of tracheal branches during entry into Drosophila flight muscles

    Julia Sauerwald et al.
    Tracheal-derived matrix metalloproteinase 1 activity sustains tracheal branch invasion into myotubes by modulating ECM properties and dynamic behavior of sprouting tip cells.

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