Browse the search results

Page 2 of 9
    1. Computational and Systems Biology
    2. Neuroscience

    Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality

    Sunitha Rangaraju et al.
    A transcriptome-based metric for aging reveals a longevity mechanism that specifically prolongs the duration of young adulthood rather than slowing overall aging.
    1. Neuroscience

    Acute inhibition of neurosteroid estrogen synthesis suppresses status epilepticus in an animal model

    Satoru M Sato, Catherine S Woolley
    Seizures stimulate estrogen synthesis in the brain and acutely inhibiting brain estrogen synthesis suppresses seizures, in both sexes, without additional interventions.
    1. Cell Biology

    Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

    Scott J Dixon et al.
    Erastin and sorafenib inhibit system xc- and induce ER stress, suggesting these may be useful tools for probing the functions of system xc- and its role in inducing ER stress and ferroptosis.
    1. Biochemistry and Chemical Biology

    Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins

    Urszula Nowicka et al.
    Defective mitochondrial protein import results in protein aggregation and a specific chaperone response in the cytosol, causatively linking mitochondrial function and cellular protein homeostasis disturbances observed in neurodegeneration.
    1. Cancer Biology

    Lipid droplets and ferritin heavy chain: a devilish liaison in human cancer cell radioresistance

    Luca Tirinato et al.
    Lipid Droplet accumulation is a fingerprint shared by different human cancer radioresistant cells and their biogenesis strongly depend on FTH1 presence.
    1. Biochemistry and Chemical Biology
    2. Ecology

    Secondary metabolites of Hülle cells mediate protection of fungal reproductive and overwintering structures against fungivorous animals

    Li Liu et al.
    Xanthones produced by the filamentous fungus Aspergillus nidulans protect its sexual structures from predation by arthropods.
    1. Neuroscience

    Seizures are a druggable mechanistic link between TBI and subsequent tauopathy

    Hadeel Alyenbaawi et al.
    A traumatic brain injury model is invented for larval zebrafish and applied to a new fluorescent 'tauopathy reporter fish', revealing a role for seizures in progression towards dementias.
    1. Biochemistry and Chemical Biology

    Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations

    Ryan R Cupo, James Shorter
    Skd3 (human ClpB) is a potent ATP-dependent mitochondrial protein disaggregase that is activated by the rhomboid protease, PARL, and inactivated by MGCA7-linked mutations.
    1. Cell Biology
    2. Neuroscience

    Specific depletion of the motor protein KIF5B leads to deficits in dendritic transport, synaptic plasticity and memory

    Junjun Zhao et al.
    Two homologous kinesin motors, KIF5A and KIF5B, have distinct functions in dendritic spine morphogenesis, and KIF5B plays a role in synaptic plasticity and memory.
    1. Neuroscience

    Insights into the dynamic control of breathing revealed through cell-type-specific responses to substance P

    Nathan A Baertsch, Jan-Marino Ramirez
    The neuromodulator substance P enhances mechanisms of recurrent excitation between breaths to control breathing frequency and stability.