524 results found
    1. Cancer Biology
    2. Computational and Systems Biology

    Optimal transport for automatic alignment of untargeted metabolomic data

    Marie Breeur, George Stepaniants ... Vivian Viallon
    A computational method based on optimal transport enables state-of-the-art alignment between untargeted metabolomic studies and is evaluated on cord blood and cancer datasets.
    1. Neuroscience

    Metabolomic profiling reveals a differential role for hippocampal glutathione reductase in infantile memory formation

    Benjamin Bessières, Emmanuel Cruz, Cristina M Alberini
    Hippocampal metabolomic analyses following episodic learning at different ages revealed a critical role for neuronal glutathione reductase activity in long-term infantile memory formation.
    1. Epidemiology and Global Health

    Early life infection and proinflammatory, atherogenic metabolomic and lipidomic profiles in infancy: a population-based cohort study

    Toby Mansell, Richard Saffery ... Barwon Infant Study Investigator Group
    More parent-reported infections in the first year of life were associated with metabolic differences linked with cardiovascular and metabolic disease in adulthood, with observational evidence for inflammation partly mediating this relationship.
    1. Evolutionary Biology

    Linking genotypic and phenotypic changes in the E. coli long-term evolution experiment using metabolomics

    John S Favate, Kyle S Skalenko ... Premal Shah
    Metabolomic analysis shows how genome-wide changes in gene expression propagate to and affect the metabolomes of an organism during adaptation.
    1. Medicine

    Metabolomics identifies and validates serum androstenedione as novel biomarker for diagnosing primary angle closure glaucoma and predicting the visual field progression

    Shengjie Li, Jun Ren ... Wenjun Cao
    Metabolomic analyses have developed and validated serum androstenedione as a reliable and effective diagnostic and predictive biomarker for primary angle closure glaucoma in clinical routines.
    1. Biochemistry and Chemical Biology

    The ‘ForensOMICS’ approach for postmortem interval estimation from human bone by integrating metabolomics, lipidomics, and proteomics

    Andrea Bonicelli, Hayley L Mickleburgh ... Noemi Procopio
    The integration of multiple omics panels obtained from bone tissue could aid in the evaluation of the postmortem interval in forensic investigations, expanding the boundaries of forensic research.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    The metabolome of Mexican cavefish shows a convergent signature highlighting sugar, antioxidant, and Ageing-Related metabolites

    J Kyle Medley, Jenna Persons ... Nicolas Rohner
    Metabolomics data reveals unique metabolic insights into how cavefish adapt to nutrient limited environments while staying healthy.
    1. Stem Cells and Regenerative Medicine

    Metabolomic profiling of rare cell populations isolated by flow cytometry from tissues

    Andrew W DeVilbiss, Zhiyu Zhao ... Sean J Morrison
    A method was developed for the metabolomic analysis of small numbers of flow cytometrically isolated cells from rare cell populations such as hematopoietic stem cells and circulating cancer cells.
    1. Ecology
    2. Evolutionary Biology

    Metabolic consequences of various fruit-based diets in a generalist insect species

    Laure Olazcuaga, Raymonde Baltenweck ... Julien Foucaud
    Metabolomic analyses indicate that diet generalism may stem from a neutral metabolic response to different chemistries, rather than from an accumulation of specific adaptations.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy

    Carlo Giannangelo, Matthew P Challis ... Darren J Creek
    M1 alanyl aminopeptidase is chemically validated as an attractive antimalarial target by confirming the on-target activity of a novel selective inhibitor using chemoproteomics and metabolomics-based drug target deconvolution approaches.

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