Marie Breeur, George Stepaniants ... Vivian Viallon
A computational method based on optimal transport enables state-of-the-art alignment between untargeted metabolomic studies and is evaluated on cord blood and cancer datasets.
Benjamin Bessières, Emmanuel Cruz, Cristina M Alberini
Hippocampal metabolomic analyses following episodic learning at different ages revealed a critical role for neuronal glutathione reductase activity in long-term infantile memory formation.
Toby Mansell, Richard Saffery ... Barwon Infant Study Investigator Group
More parent-reported infections in the first year of life were associated with metabolic differences linked with cardiovascular and metabolic disease in adulthood, with observational evidence for inflammation partly mediating this relationship.
Metabolomic analyses have developed and validated serum androstenedione as a reliable and effective diagnostic and predictive biomarker for primary angle closure glaucoma in clinical routines.
Andrea Bonicelli, Hayley L Mickleburgh ... Noemi Procopio
The integration of multiple omics panels obtained from bone tissue could aid in the evaluation of the postmortem interval in forensic investigations, expanding the boundaries of forensic research.
Andrew W DeVilbiss, Zhiyu Zhao ... Sean J Morrison
A method was developed for the metabolomic analysis of small numbers of flow cytometrically isolated cells from rare cell populations such as hematopoietic stem cells and circulating cancer cells.
Metabolomic analyses indicate that diet generalism may stem from a neutral metabolic response to different chemistries, rather than from an accumulation of specific adaptations.
Carlo Giannangelo, Matthew P Challis ... Darren J Creek
M1 alanyl aminopeptidase is chemically validated as an attractive antimalarial target by confirming the on-target activity of a novel selective inhibitor using chemoproteomics and metabolomics-based drug target deconvolution approaches.