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Metabolomics analysis identified potential neuroactive metabolites, issued from food and microbial fermentation, that are linked to symptoms of depression, anxiety and alcohol craving.

A comprehensive cross-sectional assessment reveals functional decline in mice consistent with increased energetic cost of physical activity with age through metabolic rewiring in multiple organs.

Extensive mass spectrometry-based profiling of polar metabolites within synaptic vesicles that are rapidly isolated either from cultured mouse neurons or directly from mouse brains reveals their neurotransmitter composition.

Dietary choice per se is sufficient to modulate aging in Drosophila and through serotonergic control of peripheral metabolism.

High throughput metabolome profiling of yeast cells that are dynamically perturbed with the drug rapamycin can be used to implicate new genes in the key cellular process of TOR signaling, including the gene of unknown function CFF1.

Lipoprotein particle size and composition, fatty acids, and amino acids were associated with the risk of incident diabetes, and adding the selected metabolites could significantly improve the risk prediction of progression from prediabetes to diabetes beyond the conventional clinical variables.

A human experimental model for physiological glucocorticoid exposure and glucocorticoid withdrawal identifies a multi-omic cluster, including microRNA miR-122-5p and metabolites, associated with glucocorticoid-responsive genes.

A multiomics, systems biology approach was used to define the metabolic and signaling programs that drive the fate and function of pancreatic tumor-associated macrophages.

The tyrosine degradation pathway reprogramming connects mitochondrial dysfunction, aging, and production of tyrosine-derived neuromediators that can be targeted with an FDA-approved drug, Tigecycline.

Low estrogen levels in postmenopausal hypertension are linked to metabolic reprogramming and aortic tissue changes, with L-alpha-aminobutyric acid emerging as a potential protective biomarker.