A new model for phase precession accounts for theta sequence generation, suggests critical roles for interneurons, and predicts circuit properties to optimise memory storage.
Independent coding without synaptic coordination explains complex sequences of population activity observed during theta states and maximizes the number of distinct environments that can be encoded through population theta sequences.
Random fluctuations in neuronal firing may enable a single brain region, the medial entorhinal cortex, to perform distinct roles in cognition (by generating gamma waves) and spatial navigation (by producing a grid cell map).
FRET biosensor-based measurement of cAMP signaling and single-channel recording reveal that β-blockers trigger local activation of adrenergic receptors and calcium channels in primary neurons.
Clustering the B cell receptor generates a membrane domain analogous to the liquid-ordered phase, localizing proteins involved in early receptor activation.
The INM protein LAP1B, an activator of Torsin ATPases, is a chromatin-binding factor that erroneously persists on mitotic chromatin if Torsin functionality is compromised, inducing chromosome segregation defects and binucleation.
Developmental defects of the cochlea caused by dysregulation of sonic hedgehog signaling are the potential etiology for hearing loss in a group of ciliopathies with defective ciliogenesis.
Long-term imaging of dentate granule cells reveals that the presence of synaptopodin within large spines, rather than their size, conveys long-term stability to large spines.
