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    1. Cancer Biology

    Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota

    Kathryn Eaton et al.
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but it also contains results that are not consistent with other parts of the original paper.
    1. Neuroscience
    2. Microbiology and Infectious Disease

    Social interaction-induced activation of RNA splicing in the amygdala of microbiome-deficient mice

    Roman M Stilling et al.
    Social-interaction impairment in germ-free mice is associated with a markedly altered transcriptional response to social novelty in the amygdala, as characterised by replacement of upregulation of common stimulus-induced pathways with upregulation of the splicing machinery.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The Crohn’s disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response

    Sydney Lavoie et al.
    Gnotobiotic and conventional mouse models of the IBD ATG16L1T300A SNP reveal gene-microbiota-immune interactions.
    1. Microbiology and Infectious Disease

    Special Issue: Call for papers pushing the boundaries of microbiome research

    eLife is pleased to announce Mechanistic microbiome studies: a Special Issue, curating the very best in the field of microbiome research.
    1. Microbiology and Infectious Disease

    Special Issue: New Year marks three months to submit your microbiome paper

    Presenting the very best in the field of microbiome research, our Special Issue continues to accept submissions until April 1, 2018.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Cretaceous dinosaur bone contains recent organic material and provides an environment conducive to microbial communities

    Evan T Saitta et al.
    Subterranean fossil bone hosts a living microbiome different from the surrounding sediment without evidence of original protein preservation.
    1. Plant Biology

    Antimicrobial peptide expression in a wild tobacco plant reveals the limits of host-microbe-manipulations in the field

    Arne Weinhold et al.
    The attempt to manipulate a microbiome in planta to study the ecological consequences under field conditions leaves plants and their microbes surprisingly unimpressed.
    1. Cancer Biology

    Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

    Alessandro Bitto et al.
    Three months treatment with the drug rapamycin increases lifespan, alters cancer prevalence, remodels the microbiome, and improves functional measures of health in middle aged mice in a dose- and sex-dependent manner.
    1. Microbiology and Infectious Disease

    Changes in the genetic requirements for microbial interactions with increasing community complexity

    Manon Morin et al.
    Analysis of the global genetic requirements and gene expression changes in E. coli in the presence of a simple microbiome revealed pairwise and higher-order interactions, and underlying molecular mechanisms.
    1. Cell Biology
    2. Immunology and Inflammation

    Rapamycin rejuvenates oral health in aging mice

    Jonathan Y An et al.
    Short-term treatment with rapamycin reverses periodontal bone loss, attenuates inflammation, and remodels the oral microbiome toward a more youthful state.