The recently characterized opsin group of xenopsins is likely a major player in animal eye evolution and may have been present in an ancient, highly plastic eye photoreceptor cell type.

ARHGAP18 specializes in controlling cell shape at the topmost layer of the cell membrane by regulating the interaction between the ERM protein family, RhoA signaling, and the actin cytoskeleton.

ICAM-1 engagement controls hepatic cell polarity, but this receptor can also signal without prior leukocyte interaction, thanks to its confinement into apical, microvilli-enriched, bile-canalicular domains and its actin connector EBP50.

The polarity protein crumbs controls apical secretion and the architecture of the apical domain by modulating PI(4,5)P₂ levels and the organization of apical Rab6-, Rab11-, and Rab30-dependent trafficking.

Applying a CRISPR knockout screen in polarized intestinal epithelial cells and subsequent phenotypic analyses identified various genes, of which several were previously not associated with epithelial homeostasis, to be relevant for proper epithelial polarization, apical cargo transport, and endo/lysosomal morphology.

The employment of xenopsin in ciliary and mixed microvillar/ciliary eye sensory cells in several protostome animals suggests high evolutionary plasticity of photoreceptors.

Phosphorylation of ezrin involves an unusual mechanism requiring coincident binding to PIP2 and involvement of the non-catalytic domain to gain access to the phosphorylation site thereby restricting selective phosphorylation to the plasma membrane.

Immunolabelling and morphological assessment, complemented by complete transcriptomic analysis, demonstrates that supporting cells can be induced to convert towards a hair cell-like phenotype in human vestibular sensory epithelia.

Molecular, cellular, and developmental characterization of zebrafish Merkel cells establishes a new model for the study of mechanosensory epidermal cells.

Proteins pivotal to epithelial polarization organize in separated clusters, simplifying the current view by showing that a small fraction of the many protein–protein interactions proposed are prominent in mature epithelia.