9,047 results found
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The role of Pitx2 and Pitx3 in muscle stem cells gives new insights into P38α MAP kinase and redox regulation of muscle regeneration

    Aurore L'honoré et al.
    Modulation of muscle stem cell redox state in culture both improves their amplification while maintaining a similar grafting potential as freshly isolated stem cells.
    1. Genetics and Genomics
    2. Neuroscience

    The majority of transcripts in the squid nervous system are extensively recoded by A-to-I RNA editing

    Shahar Alon et al.
    The first example of an animal where RNA-editing dramatically reshapes the entire proteome demonstrates that editing must be a critical evolutionary and adaptive force.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Mof-associated complexes have overlapping and unique roles in regulating pluripotency in embryonic stem cells and during differentiation

    Sarina Ravens et al.
    Two complexes that contain the histone acetyl transferase MOF have distinct regulatory roles in the growth and development of pluripotent embryonic stem cells
    1. Stem Cells and Regenerative Medicine

    Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

    Sophie M Morgani et al.
    Micropatterned differentiation of mouse pluripotent stem cells gives rise to regionally distinct cell types arising in embryos at gastrulation.
    1. Cell Biology
    2. Cancer Biology

    miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway

    Taichi Isobe et al.
    Insights into the roles and mechanisms of two of the miRNAs upregulated in human breast cancer stem cells in at least some breast cancers are presented.
    1. Stem Cells and Regenerative Medicine

    Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis

    Yuhua Tian et al.
    miR-31 drives proliferation of intestinal stem cells, and protects intestinal stem cells against apoptosis both during homeostasis and regeneration in response to ionizing radiation injury, and promotes intestinal tumorigenesis through regulation of multiple signaling pathways.
    1. Stem Cells and Regenerative Medicine

    A mex3 homolog is required for differentiation during planarian stem cell lineage development

    Shu Jun Zhu et al.
    The planarian mex3-1 gene is required for non-stem cell fates and suppresses a stem cell fate in differentiating cells.
    1. Developmental Biology

    Neuronal sources of hedgehog modulate neurogenesis in the adult planarian brain

    Ko W Currie et al.
    Planarian brain neurons modulate their turnover by signaling to nearby stem cells.
    1. Neuroscience

    Output variability across animals and levels in a motor system

    Angela Wenning et al.
    Population output variability in a motor control system varies across levels (CPG, motor neurons, muscles) and can be ascribed to life history differences among animals and in some cases to differences between bilaterally homologous elements.
    1. Stem Cells and Regenerative Medicine

    Stem cells repurpose proliferation to contain a breach in their niche barrier

    Kenneth Lay et al.
    Adult stem cells sense nearby tissue damage and recruit immune cells to help them direct efforts towards containing a breach in the epithelial barrier.

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