9,198 results found
    1. Chromosomes and Gene Expression

    Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice

    Liou Y Sun et al.
    Mice with a mutation that disrupts the release of growth hormone show greatly increased lifespan, which can be further increased by caloric restriction.
    1. Neuroscience

    State-dependent cell-type-specific membrane potential dynamics and unitary synaptic inputs in awake mice

    Aurélie Pala, Carl CH Petersen
    Membrane potential recordings in awake mice from two genetically defined classes of neocortical inhibitory neurons reveal their distinct patterns of activity and unitary excitatory synaptic inputs, which are differentially modulated by behavior and local network activity.
    1. Developmental Biology
    2. Evolutionary Biology

    An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice

    João PL Castro et al.
    Genome sequencing of mice selected for longer limbs reveals that rapid selection response is due to both discrete loci and polygenic adaptation.
    1. Cancer Biology

    Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

    Alessandro Bitto et al.
    Three months treatment with the drug rapamycin increases lifespan, alters cancer prevalence, remodels the microbiome, and improves functional measures of health in middle aged mice in a dose- and sex-dependent manner.
    1. Neuroscience

    Dynamics of gaze control during prey capture in freely moving mice

    Angie M Michaiel et al.
    During natural visual behavior in mice, orienting towards a target is driven by head movements, during which the eyes stabilize and shift the visual input.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Reduced expression of C/EBPβ-LIP extends health and lifespan in mice

    Christine Müller et al.
    Reduced expression of a single transcription factor is sufficient to improve fitness and health at old age and increases the lifespan in female mice.
    1. Neuroscience

    Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment

    Cemre Celen et al.
    Mirroring human patients with ARID1B mutations, Arid1b haploinsufficient mice exhibited numerous neuropsychiatric defects and revealed IGF1 deficiency related growth impairment that could be ameliorated with growth hormone supplementation.
    1. Neuroscience
    2. Microbiology and Infectious Disease

    Social interaction-induced activation of RNA splicing in the amygdala of microbiome-deficient mice

    Roman M Stilling et al.
    Social-interaction impairment in germ-free mice is associated with a markedly altered transcriptional response to social novelty in the amygdala, as characterised by replacement of upregulation of common stimulus-induced pathways with upregulation of the splicing machinery.
    1. Cancer Biology

    Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth

    Kashyap Dave et al.
    A tumor-specific regulatory region has been identified upstream of the Myc oncogene.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice

    Shrestha Ghosh et al.
    The dramatic extension of lifespan in Sirt6-deficient mice by Trp53 haploinsufficiency suggests that SIRT6 has distinct biological function from SIRT1 in regulating p53 activity and preventing cells from senescence/apoptosis.

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