6,928 results found
    1. Cell Biology

    One-shot analysis of translated mammalian lncRNAs with AHARIBO

    Luca Minati, Claudia Firrito ... Massimiliano Clamer
    Detection of translated lncRNAs through selective isolation of active ribosomes, ribosome-associated RNAs and corresponding de novo synthesised peptides.
    1. Neuroscience

    PreBötzinger complex neurons drive respiratory modulation of blood pressure and heart rate

    Clément Menuet, Angela A Connelly ... Andrew M Allen
    The PreBötzinger complex, which contains neurons that are the kernel for inspiratory rhythm generation, also contains sympathoexcitatory and parasympathoinhibitory neurons that drive respiratory-phase oscillations in blood pressure and heart rate.
    1. Computational and Systems Biology
    2. Neuroscience

    Neural correlates and determinants of approach–avoidance conflict in the prelimbic prefrontal cortex

    Jose A Fernandez-Leon, Douglas S Engelke ... Fabricio H Do Monte
    A combination of electrophysiological and optogenetic approaches revealed a causal role for glutamatergic neurons in the prelimbic cortex in regulating individual differences in decision-making strategies during a threat-avoidance vs. reward-approach conflict paradigm in rats.
    1. Immunology and Inflammation

    Kidins220 regulates the development of B cells bearing the λ light chain

    Anna-Maria Schaffer, Gina Jasmin Fiala ... Susana Minguet
    The scaffold protein Kidins220 regulates the development of λLC B cells by supporting B cell precursor survival and optimizing pre‑BCR and BCR signaling.
    1. Neuroscience

    Dopamine neuron dependent behaviors mediated by glutamate cotransmission

    Susana Mingote, Nao Chuhma ... Stephen Rayport
    The conditional reduction of glutaminase in mouse dopamine neurons selectively attenuates glutamate cotransmission at phasic frequencies, revealing the role of dopamine neuron glutamate cotransmission in the attribution of motivational salience.
    1. Neuroscience

    Dopamine neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons

    Nao Chuhma, Susana Mingote ... Stephen Rayport
    Dopamine neurons make novel glutamatergic connections to striatal cholinergic interneurons in the lateral dorsal striatum that are mediated by metabotropic glutamate receptors coupled to TrpC channels.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    The RNA helicase DDX39B activates FOXP3 RNA splicing to control T regulatory cell fate

    Minato Hirano, Gaddiel Galarza-Muñoz ... Mariano A Garcia-Blanco
    RNA processing regulates gene expression of the key transcription factor FOXP3 in T regulatory cells impacting immune tolerance and susceptibility to autoimmune disease.
    1. Cancer Biology
    2. Cell Biology

    A versatile system to record cell-cell interactions

    Rui Tang, Christopher W Murray ... Monte M Winslow
    A novel reporter system that employs cell surface antigen-nanobody pairing enables physical interaction-dependent labeling and functional modification between diverse cell types.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    The evolution of adhesiveness as a social adaptation

    Thomas Garcia, Guilhem Doulcier, Silvia De Monte
    Mathematical modeling supports a scenario where cell-cell adhesion gradually evolves through natural selection, leading to the emergence of cohesive aggregates in microbial populations.
    1. Cell Biology

    NuMA recruits dynein activity to microtubule minus-ends at mitosis

    Christina L Hueschen, Samuel J Kenny ... Sophie Dumont
    At mitosis, NuMA recruits dynein-dynactin to microtubule minus-ends, enabling robust microtubule clustering and the emergence of spindle poles.

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