204 results found
    1. Stem Cells and Regenerative Medicine
    2. Immunology and Inflammation

    MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice

    Jimmy L Zhao, Dinesh S Rao ... David Baltimore
    Chronic and excessive inflammation can lead to exhaustion of the supply of hematopoietic stem cells and to myeloid malignancies in mice, mimicking important aspects of the myelodysplastic syndrome found in humans.
    1. Developmental Biology

    Deregulated FGF and homeotic gene expression underlies cerebellar vermis hypoplasia in CHARGE syndrome

    Tian Yu, Linda C Meiners ... M Albert Basson
    Mutations in CHD7, which cause CHARGE syndrome, cause a reduction in FGF8 signalling and subsequent abnormalities in the cerebellar vermis in both mice and humans.
    1. Neuroscience

    Fast transient networks in spontaneous human brain activity

    Adam P Baker, Matthew J Brookes ... Mark Woolrich
    Non-invasive MEG recordings reveal that patterns of spontaneous activity in the resting brain are shorter lived than previously thought.
    1. Ecology
    2. Epidemiology and Global Health

    Hidden shift of the ionome of plants exposed to elevated CO2 depletes minerals at the base of human nutrition

    Irakli Loladze
    Increasing levels of atmospheric carbon dioxide reduce the mineral content but increase the levels of starch and sugars found in crop plants; which could exacerbate both obesity and malnutrition in some human populations.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis

    Romeo Papazyan, Ekaterina Voronina ... Sean D Taverna
    A previously unappreciated histone methylation pathway helps limit DNA double-strand break formation and recombination in heterochromatin during meiosis.
    1. Neuroscience

    Corticothalamic phase synchrony and cross-frequency coupling predict human memory formation

    Catherine M Sweeney-Reed, Tino Zaehle ... Alan Richardson-Klavehn
    Direct electrophysiological evidence demonstrates a role for the anterior thalamic nucleus in human memory formation.
    1. Neuroscience

    A highly tunable dopaminergic oscillator generates ultradian rhythms of behavioral arousal

    Ian D Blum, Lei Zhu ... Kai-Florian Storch
    An internal clock based on brain levels of dopamine works with the circadian clock to maintain daily patterns of alertness and activity, and may be implicated in the altered behavioral patterns seen in schizophrenia and bipolar disorder.
    1. Ecology
    2. Plant Biology

    Natural genetic variation in Arabidopsis thaliana defense metabolism genes modulates field fitness

    Rachel Kerwin, Julie Feusier ... Daniel J Kliebenstein
    Environmental heterogeneity may contribute to the high levels of genetic variation in glucosinolate genes found in Arabidopsis thaliana.
    1. Computational and Systems Biology
    2. Neuroscience

    Speech encoding by coupled cortical theta and gamma oscillations

    Alexandre Hyafil, Lorenzo Fontolan ... Anne-Lise Giraud
    Computational modelling shows that coupled theta and gamma oscillations in the auditory cortex can decompose speech into its syllabic constituents, and organize the neural spiking at faster timescale into a decodable format.

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