The lysosomal ion channel TPC2 emerges as an example of an ion channel in which ion selectivity is not fixed but rather agonist-selective.

Epigenomic and transcriptomic analysis reveals that paternal obesity influences sperm histone H3 lysine 4 tri-methylation enrichment and placenta gene expression, which in turn negatively impact its development and function in a manner that may contribute to metabolic disease in offspring.

A new method to infer the spatial history of genetic ancestors from a sequence of trees along a recombining genome.

The primary rhythm generators controlling respiration are integrated in a much larger network of brain regions, including areas not typically considered to be respiratory control centers, and that allow respiration to be adapted to all forms of ongoing behavior.

A novel co-translational mechanism continuously adjusts the expression levels of ribosomal proteins Rpl3 and Rpl4 to their consumption during ribosome synthesis by regulating the abundance of their mRNAs.

A series of compounds were synthesized and demonstrated to form a specific covalent bond with His64 of CAIX, an anticancer target, a strategy applicable to any drug design project.

A biologically plausible model of myelin plasticity demonstrates how oligodendrocytes can selectively adjust conduction delays in axon bundles to allow robust communication between brain regions through long-range synchronization.

Methodology to annotate the multiple origins of axonal projections in dense electron microscopy data of mammalian nervous tissue without the need of chemical label conversion is reported.