1,385 results found
    1. Microbiology and Infectious Disease
    Mosquito infection by gametocytes from cultures exposed to dihydroartemisinin (DHA) from Figure 2, Portugaliza et al.

    Malaria: A Collection of Articles

    Edited by Olivier Silvie et al.
    eLife has recently published a wide range of papers on malaria, covering a diversity of themes including parasite biology, epidemiology, immunology, drugs and vaccines.
    1. Cancer Biology
    2. Immunology and Inflammation

    Discovery and Translation of Cancer Immunology: A Special Issue

    Edited by Jeffrey Settleman et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of the immune response to cancer cells.
    1. Chromosomes and Gene Expression
    2. Cell Biology

    Aging, Geroscience and Longevity: A Special Issue

    Edited by Matt Kaeberlein et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of aging and interventions that extend longevity.
    1. Microbiology and Infectious Disease

    Mechanisms of virus dissemination in bone marrow of HIV-1–infected humanized BLT mice

    Mark S Ladinsky et al.
    Large-volume light microscopy combined with higher-resolution electron tomography revealed the spatial distribution of virus-producing cells and highlighted mechanisms of HIV-1 dissemination in bone marrow from a small animal model.
    1. Structural Biology and Molecular Biophysics

    Real time dynamics of Gating-Related conformational changes in CorA

    Martina Rangl et al.
    High-speed atomic force microscopy reveals that the open state of the divalent ion channel CorA is highly dynamic and defined by the fast exchange between conformations.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Demographic reconstruction from ancient DNA supports rapid extinction of the great auk

    Jessica E Thomas et al.
    Reconstruction of great auk population dynamics suggests that hunting pressure alone could have been responsible for their extinction, demonstrating that even abundant, widespread species can be vulnerable to intense exploitation.
    1. Immunology and Inflammation

    Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy

    Alok Kumar et al.
    Downregulation of mitochondrial activity by immunosuppressive tumor-derived soluble factors leads to systemic unresponsiveness to the PD-1 blockade therapy.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation

    Richard S Marshall, Richard D Vierstra
    Proteasomes are protected from autophagic elimination upon carbon starvation by sequestration into cytoplasmic storage granules, which aid cell fitness by providing a cache of proteasomes that can be rapidly remobilized when carbon availability improves.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells

    Osama F Harraz et al.
    TRPV4 channels in brain capillaries are suppressed by the phosphoinositide PIP2 and activated by receptor agonists implicated in neurovascular coupling.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Sec17/Sec18 act twice, enhancing membrane fusion and then disassembling cis-SNARE complexes

    Hongki Song et al.
    Sec17 (αSNAP) and Sec18 (NSF) are shown to act twice, to promote fusion per se and to recycle SNAREs after fusion.

Refine your results by:

Type
Research categories